ArticleAmerican journal of Alzheimer's disease and other dementias2016
Neural Underpinnings of the Decline of Topographical Memory in Mild Cognitive Impairment.
Article in American journal of Alzheimer's disease and other dementias, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Spatial navigation skills in older adults with and without cognitive impairment.Frontiers in aging · 2025Article
- Embodied Spatial Navigation Training in Mild Cognitive Impairment: A Proof-of-Concept Trial.Journal of Alzheimer's disease : JAD · 2024Article
- Bodily and Visual-Cognitive Navigation Aids to Enhance Spatial Recall in Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Anodal transcranial direct current stimulation alleviates cognitive impairment in an APP/PS1 model of Alzheimer's disease in the preclinical stage.Neural regeneration research · 2022Article
- Cerebellum-Cortical Interaction in Spatial Navigation and Its Alteration in Dementias.Brain sciences · 2022Review
- Overcoming navigational challenges: A novel approach to the study and assessment of topographical orientation.Behavior research methods · 2022Article
- Spatial memory deficits in Alzheimer's disease and their connection to cognitive maps' formation by place cells and grid cells.Frontiers in behavioral neuroscience · 2022Review
- Longitudinal Assessment of Working Memory Performance in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease Using an Automated Figure-8-Maze.Frontiers in behavioral neuroscience · 2021Article
- The differential effect of normal and pathological aging on egocentric and allocentric spatial memory in navigational and reaching space.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Voice quality and speech fluency distinguish individuals with Mild Cognitive Impairment from Healthy Controls.PloS one · 2020Article
- Does spatial cognitive style affect how navigational strategy is planned?Experimental brain research · 2019Article
- Topographical disorientation in aging. Familiarity with the environment does matter.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Review
- Disentangling the Contribution of Spatial Reference Frames to Executive Functioning in Healthy and Pathological Aging: An Experimental Study with Virtual Reality.Sensors (Basel, Switzerland) · 2018Article
- Missing the egocentric spatial reference: a blank on the map.F1000Research · 2018Review
- Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.Neuropsychologia · 2017Article
- Effect of Cognitive Style on Learning and Retrieval of Navigational Environments.Frontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial navigation is one of the cognitive functions known to decline in both normal and pathological aging. In the present study, we aimed to assess the neural correlates of the decline of topographical memory in patients with amnestic mild cognitive impairment (aMCI). Patients with aMCI and age-matched controls were engaged in an intensive learning paradigm, lasting for 5 days, during which they had to encode 1 path from an egocentric perspective and 1 path from an allocentric perspective. After the learning period, they were asked to retrieve each of these paths using an allocentric or egocentric frame of reference while undergoing a functional magnetic resonance imaging scan. We found that patients with aMCI showed a specific deficit in storing new topographical memories from an allocentric perspective and retrieving stored information to perform the egocentric task. Imaging data suggest that this general decline is correlated with hypoactivation of the brain areas generally involved in spatial navigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.