ReviewNature reviews. Neuroscience2016
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.
Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 457 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
457 citing papers in PubMed, 3 syntheses or guidelines pooled it, 763 citations in OpenAlex.
- Functional Magnetic Resonance Imaging of Post-Traumatic Headache: A Systematic Review.Current pain and headache reports · 2025Pooled it
- Structural Magnetic Resonance Imaging of Post-Traumatic Headache: A Systematic Review.Current pain and headache reports · 2025Pooled it
- Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review.Frontiers in neurology · 2025Pooled it
- Trial
- Trial
- cGAS-STING signaling in the anterior cingulate cortex modulates electroacupuncture analgesia in a rat neuropathic pain model.The Korean journal of pain · 2026Article
- AMPA receptor, neuroimaging, and chronic pain.Journal of anesthesia · 2026Review
- YTHDF1 modulates CAP1-mediated actin turnover to regulate synaptic function and anxiodepressive-like behaviors.Molecular psychiatry · 2026Article
- Chronic pain after thoracic surgery: mechanisms, risk factors, and limitations of current preventive strategies-a narrative review.Journal of thoracic disease · 2026Review
- GluK1-containing kainate receptor-dependent long-term depression in the anterior cingulate cortex modulates chronic pain.Journal of translational medicine · 2026Article
- Temporal Transcriptomic Changes in the Cingulate Cortex of Neuropathic Pain Mice.Biomedicines · 2026Article
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- TRPC4/TRPC5 are critical for neuronal modulation by transcranial focused ultrasound in retrosplenial cortex in male mice.Nature communications · 2026Article
- Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.Research square · 2026Article
- 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway.Cell research · 2026Article
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- Neural Excitation-Inhibition Imbalance in Cervical Spondylotic Myelopathy.Communications medicine · 2026Article
- A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain-induced depression in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Virtual Reality as a Digital Premedication to Alleviate Preoperative Anxiety and Postoperative Pain in Patients Undergoing Spine Surgery: Study Protocol for a Randomized Clinical Trial.Brain sciences · 2026Article
- AScience signaling · 2026Article
397 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.