ArticlePathogens and disease2016
pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children.
Article in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 20 citations in OpenAlex.
- Incidence and aetiology of diarrhoeal disease among children under five years in the post-rotavirus vaccine introduction era in Manhiça District, Mozambique.Tropical medicine and health · 2026Article
- EnteroaggregativeEcoSal Plus · 2025Review
- Enteroaggregative Escherichia coli (EAEC) isolates obtained from non-diarrheic children carry virulence factor-encoding genes from Extraintestinal Pathogenic E. Coli (ExPEC).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study.PLoS neglected tropical diseases · 2020Article
- Pic-ProducingInternational journal of molecular sciences · 2020Article
- Surface Protein Dispersin of EnteroaggregativeFrontiers in microbiology · 2020Article
- Analysis of the Virulence Profile and Phenotypic Features of Typical and Atypical EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Virulence gene profiles ofPathogens and global health · 2019Article
- Molecular and Phenotypic Characterization of DiarrheagenicThe American journal of tropical medicine and hygiene · 2017Article
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea among children, HIV-infected patients, and travelers to developing countries. We have searched for 18 genes-encoding virulence factors associated with aggregative adherence, dispersion, biofilm, toxins, serine protease autotransporters of Enterobacteriaceae (SPATEs) and siderophores, analyzed in 172 well-characterized EAEC strains (aggR(+)) isolated from stool samples of 97 children with diarrhea and 75 healthy controls from a passive surveillance diarrhea cohort study in Peru. Eighty-one different genetic profiles were identified, 37 were found only associated with diarrhea and 25 with control samples. The most frequent genetic profile was aggC(+)aatA(+)aap(+)shf(+)fyuA(+), present in 19 strains, including diarrhea and controls. The profile set1A(+)set1B(+)pic(+) was associated with diarrhea (P < 0.05). Of all genes evaluated, the most frequent were aatA (CVD 342) present in 159 strains (92.4%) and fyuA in 157 (91.3%). When EAEC strains were analyzed as a single pathogen (excluding co-infections), only pic was associated with diarrhea (P < 0.05) and with prolonged diarrhea (diarrhea ≥ 7 days) (P < 0.05). In summary, this is the first report on the prevalence of a large set of EAEC virulence genes and its association with diarrhea in Peruvian children. More studies are needed to elucidate the exact role of each virulence factor.
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