Evidence map›Paper›PMID 27306914›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Radiotherapy-related intracranial aneurysm: case presentation of a 17-year male and a meta-analysis based on individual patient data.

Yuan-Hung Wu, Sheng-Shuan Lin, Hsin-Hung Chen, Feng-Chi Chang, Muh-Lii Liang, Tai-Tong Wong, Sang-Hue Yen, Yi-Wei Chen

Abstract readCase ReportsMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Radiation Vasculopathy.Cerebrovascular diseases extra · 2025
    Review
  2. Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
    Article
  3. Review
  4. Article
  5. Radiation-induced intracranial aneurysm presenting with acute hemorrhage in a child treated for medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yuan-Hung WuDepartment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Sheng-Shuan LinDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hsin-Hung ChenNeurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Feng-Chi ChangSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Muh-Lii LiangNeurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Tai-Tong WongNeurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Sang-Hue YenDepartment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Wei ChenDepartment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. chenyw@vghtpe.gov.tw.ORCID http://orcid.org/0000-0003-3946-7540
National Yang Ming Chiao Tung University · TWHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the incidence, clinical profiles, latency, and outcomes of radiotherapy (RT)-related intracranial aneurysms, rare but often fatal complications of cranial irradiation.

methodsWe reviewed all published individual patient data regardless of language, using survival analysis to make statistical inferences.

resultsWe examined a total of 58 patients with RT-related intracranial aneurysms, including one unpublished case presented here, of whom 74.1 % presented with rupture. In the study, 29.3 % were younger than 18 years. The mean age at which patients received the first course of RT was 34.8 ± 22.8 years old. The mean latency between initiating RT and presenting with aneurysm was 10.4 ± 8.5 years. Rapid death ensured in 24 % shortly after presentation. The only significant predictor of death was rupture. In those with a single aneurysm, 43.1 % were located at the internal carotid artery, while 15.5 % of patients had multiple aneurysms. A male-to-female ratio of 1.87, 0.5, and 1.32 was found in patients younger than age 52, 52 years of age or older, and all 58 patients, respectively. Older age when receiving RT and presentation with ruptured aneurysm were significantly associated with shorter latency.

conclusionsRT-related intracranial aneurysms presented differently from classical ones based on age, sex, site, multiplicity, and type. Sex ratios differed with age. The younger age group showed a longer latency of occurrence of an aneurysm. Older patients and those who develop ruptured aneurysms presented earlier. Since rupture may affect outcome, early detection of aneurysms before rupture may save lives.

Indexed as

AdolescentAdultAneurysm, RupturedCerebral AngiographyFemaleHumansIntracranial AneurysmMaleMiddle AgedRadiation InjuriesStatistics as TopicYoung AdultAneurysmRadiation toxicityRadiotherapyVasculopathy

Identifiers

PMID27306914
OpenAlexW2431759345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.