ArticleJournal of neurophysiology2016
Self-reinnervated muscles lose autogenic length feedback, but intermuscular feedback can recover functional connectivity.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Protocol for direct in vivo evaluation of the stretch reflex in adult mice.STAR protocols · 2026Article
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Hindlimb muscle spindles inform preparatory forelimb coordination prior to landing in toads.The Journal of experimental biology · 2023Article
- Electrical Stimulation of Distal Tibial Nerve During Stance Phase of Walking May Reverse Effects of Unilateral Paw Pad Anesthesia in the Cat.Motor control · 2023Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Non-uniform upregulation of the autogenic stretch reflex among hindlimb extensors following lateral spinal lesion in the cat.Experimental brain research · 2021Article
- Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.Journal of neuroscience research · 2020Article
- Article
- Adaptation to slope in locomotor-trained spinal cats with intact and self-reinnervated lateral gastrocnemius and soleus muscles.Journal of neurophysiology · 2020Article
- Evaluating intermuscular Golgi tendon organ feedback with twitch contractions.The Journal of physiology · 2019Article
- The modulation of locomotor speed is maintained following partial denervation of ankle extensors in spinal cats.Journal of neurophysiology · 2018Article
- Time course of functional recovery during the first 3 mo after surgical transection and repair of nerves to the feline soleus and lateral gastrocnemius muscles.Journal of neurophysiology · 2018Article
- Distributed force feedback in the spinal cord and the regulation of limb mechanics.Journal of neurophysiology · 2018Review
- Patterns of intermuscular inhibitory force feedback across cat hindlimbs suggest a flexible system for regulating whole limb mechanics.Journal of neurophysiology · 2018Article
- VGLUT1 synapses and P-boutons on regenerating motoneurons after nerve crush.The Journal of comparative neurology · 2017Article
- Musculotendon adaptations and preservation of spinal reflex pathways following agonist-to-antagonist tendon transfer.Physiological reports · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, we sought to identify sensory circuitry responsible for motor deficits or compensatory adaptations after peripheral nerve cut and repair. Self-reinnervation of the ankle extensor muscles abolishes the stretch reflex and increases ankle yielding during downslope walking, but it remains unknown whether this finding generalizes to other muscle groups and whether muscles become completely deafferented. In decerebrate cats at least 19 wk after nerve cut and repair, we examined the influence of quadriceps (Q) muscles' self-reinnervation on autogenic length feedback, as well as intermuscular length and force feedback, among the primary extensor muscles in the cat hindlimb. Effects of gastrocnemius and soleus self-reinnervation on intermuscular circuitry were also evaluated. We found that autogenic length feedback was lost after Q self-reinnervation, indicating that loss of the stretch reflex appears to be a generalizable consequence of muscle self-reinnervation. However, intermuscular force and length feedback, evoked from self-reinnervated muscles, was preserved in most of the interactions evaluated with similar relative inhibitory or excitatory magnitudes. These data indicate that intermuscular spinal reflex circuitry has the ability to regain functional connectivity, but the restoration is not absolute. Explanations for the recovery of intermuscular feedback are discussed, based on identified mechanisms responsible for lost autogenic length feedback. Functional implications, due to permanent loss of autogenic length feedback and potential for compensatory adaptations from preserved intermuscular feedback, are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.