ArticleJournal of neurophysiology2016
Synaptic and intrinsic homeostasis cooperate to optimize single neuron response properties and tune integrator circuits.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits.bioRxiv : the preprint server for biology · 2025Article
- Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.PLoS computational biology · 2025Article
- Reliability and robustness of oscillations in some slow-fast chaotic systems.Chaos (Woodbury, N.Y.) · 2023Article
- Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.PLoS biology · 2023Article
- Combined mechanisms of neural firing rate homeostasis.Biological cybernetics · 2019Review
- Stable Control of Firing Rate Mean and Variance by Dual Homeostatic Mechanisms.Journal of mathematical neuroscience · 2017Article
- Exploring the Role of CaMKIV in Homeostatic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- All for One But Not One for All: Excitatory Synaptic Scaling and Intrinsic Excitability Are Coregulated by CaMKIV, Whereas Inhibitory Synaptic Scaling Is Under Independent Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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2 authors.
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Abstract
Homeostatic processes that provide negative feedback to regulate neuronal firing rate are essential for normal brain function, and observations suggest that multiple such processes may operate simultaneously in the same network. We pose two questions: why might a diversity of homeostatic pathways be necessary, and how can they operate in concert without opposing and undermining each other? To address these questions, we perform a computational and analytical study of cell-intrinsic homeostasis and synaptic homeostasis in single-neuron and recurrent circuit models. We demonstrate analytically and in simulation that when two such mechanisms are controlled on a long time scale by firing rate via simple and general feedback rules, they can robustly operate in tandem to tune the mean and variance of single neuron's firing rate to desired goals. This property allows the system to recover desired behavior after chronic changes in input statistics. We illustrate the power of this homeostatic tuning scheme by using it to regain high mutual information between neuronal input and output after major changes in input statistics. We then show that such dual homeostasis can be applied to tune the behavior of a neural integrator, a system that is notoriously sensitive to variation in parameters. These results are robust to variation in goals and model parameters. We argue that a set of homeostatic processes that appear to redundantly regulate mean firing rate may work together to control firing rate mean and variance and thus maintain performance in a parameter-sensitive task such as integration.
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