Evidence map›Paper›PMID 27306673›Full record

ArticleJournal of neurophysiology2016

Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.

S M Turner, M K ElMallah, A K Hoyt, J J Greer, D D Fuller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Obstructive sleep apnea.Handbook of clinical neurology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

S M TurnerDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida; McKnight Brain Institute, University of Florida, Gainesville, Florida; and Center for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida.
M K ElMallahDepartment of Pediatrics, Division of Pulmonary Medicine, College of Medicine, University of Florida, Gainesville, Florida;
A K HoytDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida;
J J GreerDepartment of Physiology, University of Alberta, Edmonton, Canada;
D D FullerDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida; McKnight Brain Institute, University of Florida, Gainesville, Florida; and Center for Respiratory Research and Rehabilitation, University of Florida, Gainesville, Florida ddf@phhp.ufl.edu.
University of Florida · USUniversity of Alberta · CA

Funding

Novel Approaches for Correcting Respiratory Insufficiency in Pompe DiseaseK08HD077040 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ELMALLAH, MAI · 2014 to 2018
$690k
Canadian Institutes for Health ResearchNICHD NIH HHS K08 HD077040
6 · The paper itself

Abstract

Glutamatergic currents play a fundamental role in regulating respiratory motor output and are partially mediated by α-amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA) receptors throughout the premotor and motor respiratory circuitry. Ampakines are pharmacological compounds that enhance glutamatergic transmission by altering AMPA receptor channel kinetics. Here, we examined if ampakines alter the expression of respiratory long-term facilitation (LTF), a form of neuroplasticity manifested as a persistent increase in inspiratory activity following brief periods of reduced O2 [intermittent hypoxia (IH)]. Current synaptic models indicate enhanced effectiveness of glutamatergic synapses after IH, and we hypothesized that ampakine pretreatment would potentiate IH-induced LTF of respiratory activity. Inspiratory bursting was recorded from the hypoglossal nerve of anesthetized and mechanically ventilated mice. During baseline (BL) recording conditions, burst amplitude was stable for at least 90 min (98 ± 5% BL). Exposure to IH (3 × 1 min, 15% O2) resulted in a sustained increase in burst amplitude (218 ± 44% BL at 90 min following final bout of hypoxia). Mice given an intraperitoneal injection of ampakine CX717 (15 mg/kg) 10 min before IH showed enhanced LTF (500 ± 110% BL at 90 min). Post hoc analyses indicated that CX717 potentiated LTF only when initial baseline burst amplitude was low. We conclude that under appropriate conditions ampakine pretreatment can potentiate IH-induced respiratory LTF. These data suggest that ampakines may have therapeutic value in the context of hypoxia-based neurorehabilitation strategies, particularly in disorders with blunted respiratory motor output such as spinal cord injury.

Indexed as

Action PotentialsAnimalsHypoglossal NerveHypoxiaIsoxazolesLong-Term PotentiationMaleMice, 129 StrainModels, AnimalNeurological RehabilitationPeripheral Nervous System AgentsRespirationRespiration, ArtificialCX717IsoxazolesPeripheral Nervous System AgentsAMPAmouseplasticityrespiratory

Identifiers

PMID27306673
PMCPMC5018053
OpenAlexW2444692224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.