Evidence map›Paper›PMID 27306645›Full record

ReviewMolecules and cells2016

The Role of Lymphatic Niches in T Cell Differentiation.

Tara Capece, Minsoo Kim

Abstract readReview
In one paragraph

Review in Molecules and cells, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Characterizing the immune response toFrontiers in immunology · 2024
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Tracing Antiviral CD8Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
  7. Recent advances in CD8Oncology letters · 2018
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tara CapeceDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Minsoo KimDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA.

Funding

Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Minsoo Kim · 2014 to 2026
$26.0M
LFA-1 in Lymphocyte MigrationR01HL087088 · NHLBI · UNIVERSITY OF ROCHESTER · PI KIM, MINSOO · 2007 to 2015
$3.8M
Regulation of integrin LFA-1 during T cell migration and activationF31AI112257 · NIAID · UNIVERSITY OF ROCHESTER · PI CAPECE, TARA · 2014 to 2016
$103k
NHLBI NIH HHS R01 HL087088NIAID NIH HHS F31 AI112257NIAID NIH HHS P01 AI102851
6 · The paper itself

Abstract

Long-term immunity to many viral and bacterial pathogens requires CD8(+) memory T cell development, and the induction of long-lasting CD8(+) memory T cells from a naïve, undifferentiated state is a major goal of vaccine design. Formation of the memory CD8(+) T cell compartment is highly dependent on the early activation cues received by naïve CD8(+) T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.

Indexed as

Stem Cell NicheAnimalsCD8-Positive T-LymphocytesCell DifferentiationDrug DesignHumansImmunologic MemoryLymph NodesVaccinesVaccinesCD8 T cellchemokineimmune memorylymph nodeT cell

Identifiers

PMID27306645
PMCPMC4959015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.