ArticleThe Journal of infection2016
Genetic characterization of human bocavirus among children with severe acute respiratory infection in China.
Article in The Journal of infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Genetic characteristics of human bocavirus in children with acute respiratory tract infections during 2023 in Beijing, China.Virology journal · 2025Article
- Prevalence and molecular characterization of human bocavirus in children with acute gastroenteritis in Beijing, China, during 2014-2023.Microbiology spectrum · 2025Article
- The prevalence and genetic characteristics of human bocavirus in patients with acute respiratory infection in China during 2012-2021.Biosafety and health · 2025Article
- Molecular epidemiological characterization of human bocavirus (HBoV) in acute respiratory infection (ARI) patients in Yucheng, China.Frontiers in public health · 2025Article
- Article
- The role of human bocavirus as an agent of community-acquired pneumonia in children under 5 years of age in Fortaleza, Ceará (Northeast Brazil).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Prevalence and Molecular Characterization of Human Bocavirus Detected in Croatian Children with Respiratory Infection.Viruses · 2021Article
- Prevalence and Genetic Characteristics of Human Bocaviruses Detected in Patients with Acute Respiratory Infections in Bulgaria.International journal of microbiology · 2021Article
- Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China.BMC infectious diseases · 2019Article
- Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia.The Journal of infection · 2018Article
- The first genome sequences of human bocaviruses from Vietnam.Wellcome open research · 2016Article
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Authors and funding
7 authors.
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Abstract
objectivesTo investigate the genetic character of Human bocavirus (HBoV) among children with severe acute respiratory infection (SARI) in China.
methodsWe screened 993 respiratory samples for HBoV by PCR among hospitalized children with SARI between September 2007 and March 2014. Four of HBoV1 samples were selected for complete genomes analysis by next-generation sequencing.
resultsThe results show that 200 (20.1%) out of 993 samples were HBoV-positive, most of these HBoV belong to HBoV1 subtype (n = 197), HBoV2 (n = 1) and HBoV3 (n = 2) were also detected. Fifty (5.04%) of 993 SARI patient were detected as HBoV-positive only. Four HBoV1 genomes in this study were conserved and showed no significant difference among the nucleotide diversity from different regions. Analyses of evolutionary rates showed that NS1 exhibited the highest degree of conservation while the VP1 gene exhibited the fastest rate of evolution at 4.20 × 10(-4) substitutions/site/year. The nucleotide deletions and substitutions occurred in NP1 and VP1 represented novel molecular signatures enabling subtype differentiation between HBoVs.
conclusionsWe described some new characteristics in the epidemiology of HBoV among children with SARI, these data will significantly expand the current knowledge of HBoV epidemic and genomic characterization among children with SARI.
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