Evidence map›Paper›PMID 27306378›Full record

ArticleMalaria journal2016

Post-deployment effectiveness of malaria control interventions on Plasmodium infections in Madagascar: a comprehensive phase IV assessment.

Thomas Kesteman, Milijaona Randrianarivelojosia, Patrice Piola, Christophe Rogier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Thomas KestemanMalaria Research Unit, Institut Pasteur de Madagascar, BP 1274, 101, Avaradoha, Antananarivo, Madagascar. thomask@pasteur.mg.ORCID 0000-0002-7951-8261
Milijaona RandrianarivelojosiaMalaria Research Unit, Institut Pasteur de Madagascar, BP 1274, 101, Avaradoha, Antananarivo, Madagascar.
Patrice PiolaEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274, 101 Avaradoha, Antananarivo, Madagascar.
Christophe RogierMalaria Research Unit, Institut Pasteur de Madagascar, BP 1274, 101, Avaradoha, Antananarivo, Madagascar.
Institut Pasteur de Madagascar · MGUnité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause international funding for malaria control is plateauing, affected countries that receive foreign funding are expected to maintain a constant budget while continuing to reduce Plasmodium transmission. To investigate the appropriateness of a malaria control policy in Madagascar, the effectiveness of all currently deployed malaria control interventions (MCIs) was measured.

methodsA nationwide cross-sectional survey was conducted in 2012-2013 at 62 sites throughout Madagascar. A total of 15,746 individuals of all ages were tested for Plasmodium infection using rapid diagnostic tests and were interviewed about their use of long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), intermittent preventive treatment of pregnant women (IPTp), and exposure to information, education and communication (IEC) campaigns. The association between Plasmodium infection and MCI exposure was calculated using multivariate multilevel models, and the protective effectiveness (PE) of an intervention was defined as one minus the odds ratio of this association.

resultsThe individual PE of regular LLIN use was high and significant (41 %, 95 % confidence interval [CI] 23-54), whereas its community PE was not. The PE of IRS at the household level was significant in one transmission pattern only (44 %, 95 % CI 11-65), and the community PE with high IRS coverage (>75 %) was high and significant overall (78 %, 95 % CI 44-91). Using LLINs after IRS increased the PE, and the reciprocal was also true. The maternal PE of IPTp was high but non-significant (65 %, 95 % CI -32 to 91). The PE of IEC was low, non-significant and restricted to certain areas (24 %, 95 % CI -34 to 57).

conclusionsThis snapshot of the effectiveness of MCIs confirms that integrated vector control is required in malaria control policies in Madagascar and suggests combining MCIs when one is questionable. Policymakers should consider the local effectiveness of all deployed MCIs through a similar phase IV assessment.

Indexed as

Health Services ResearchAdolescentAdultAgedAged, 80 and overChildCommunicable Disease ControlCross-Sectional StudiesDiagnostic Tests, RoutineDisease Transmission, InfectiousFemaleHealth EducationHumansInfantMadagascarMalariaCross-sectional studiesHealth surveysMalariaPrevalencePrevention and control

Identifiers

PMID27306378
PMCPMC4910239
OpenAlexW2427222327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.