ArticleSchizophrenia bulletin2017
Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.Bipolar disorders · 2026Article
- Clarifying Cognitive Control Deficits in Psychosis via Drift Diffusion Modeling and Attractor Dynamics.Schizophrenia bulletin · 2024Article
- Biomarkers for Cognitive Control, Response Inhibition, Aggressivity, Impulsivity, and Violence.Advances in neurobiology · 2024Review
- Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis.Brain, behavior, and immunity · 2023Article
- Evaluating causal psychological models: A study of language theories of autism using a large sample.Frontiers in psychology · 2023Article
- Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis.Molecular psychiatry · 2021Article
- Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.Molecular psychiatry · 2021Article
- Global disruption in excitation-inhibition balance can cause localized network dysfunction and Schizophrenia-like context-integration deficits.PLoS computational biology · 2021Article
- Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis.Schizophrenia bulletin · 2020Article
- Relationship of prolonged acoustic startle latency to diagnosis and biotype in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) cohort.Schizophrenia research · 2020Article
- Connectivity of the Frontal Cortical Oscillatory Dynamics Underlying Inhibitory Control During a Go/No-Go Task as a Predictive Biomarker in Major Depression.Frontiers in psychiatry · 2020Article
- Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.Neuropsychology review · 2018Review
- Longitudinal stability of cognitive control in early psychosis: Nondegenerative deficits across diagnoses.Journal of abnormal psychology · 2018Article
- Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia.Schizophrenia bulletin · 2018Article
- Deficits in visual working-memory capacity and general cognition in African Americans with psychosis.Schizophrenia research · 2018Article
- Levels of Cognitive Control: A Functional Magnetic Resonance Imaging-Based Test of an RDoC Domain Across Bipolar Disorder and Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Prefrontal-hippocampal interactions in episodic memory.Nature reviews. Neuroscience · 2017Review
- The Processing-Speed Impairment in Psychosis Is More Than Just Accelerated Aging.Schizophrenia bulletin · 2017Article
Corrections and comments
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
Abstract
Background: Context processing may reflect a specific cognitive impairment in schizophrenia. Whether impaired context processing is observed across psychotic disorders or among relatives of affected individuals, and whether it is a deficit that is independent from the generalized neuropsychological deficits seen in psychotic disorders, are less established. Methods: Schizophrenia, schizoaffective, and psychotic bipolar probands (n = 660), their first-degree relatives (n = 741), and healthy individuals (n = 308) studied by the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium performed an expectancy task requiring use of contextual information to overcome a pre-potent response. Sensitivity for target detection and false alarm rates on trials requiring inhibition or goal maintenance were measured. Results: Proband groups and relatives with psychosis spectrum personality traits demonstrated reduced target sensitivity and elevated false alarm rates. False alarm rate was higher under inhibition vs goal maintenance conditions although this difference was attenuated in schizophrenia and schizoaffective proband groups. After accounting for global neuropsychological impairment, as reflected by the composite score from the Brief Assessment of Cognition in Schizophrenia neuropsychological battery, deficits in schizophrenia and bipolar proband groups were no longer significant. Performance measures were moderately familial. Conclusion: Reduced target detection, but not a specific deficit in context processing, is observed across psychotic disorders. Impairments in both goal maintenance and response inhibition appear to contribute comparably to deficits in schizophrenia and schizoaffective disorder, whereas greater difficulty with response inhibition underlies deficits in bipolar disorder. Yet, these deficits are not independent from the generalized neurocognitive impairment observed in schizophrenia and psychotic bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.