Evidence map›Paper›PMID 27306307›Full record

ArticleAnnual review of analytical chemistry (Palo Alto, Calif.)2016

In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy.

Chien-Sheng Liao, Ji-Xin Cheng

Abstract read
In one paragraph

Article in Annual review of analytical chemistry (Palo Alto, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chien-Sheng LiaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907; email: liao44@purdue.edu.
Ji-Xin ChengWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907; email: liao44@purdue.edu.

Funding

Sensing Vulnerable Plaque in vivo by an All-optical Intravascular Ultrasound and Photoacoustic CatheterR01HL125385 · NHLBI · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2015 to 2023
$4.6M
High-throughput high-content single cell analysis by multichannel stimulatedRaman flow cytometryR01GM118471 · NIGMS · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2016 to 2019
$1.6M
Quantitative Spectroscopic Imaging of Cancer Metabolites in Live Cells and IntactR21CA182608 · NCI · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2013 to 2015
$654k
Microsecond Raman spectroscopy: Assessing single cell metabolism in a vital organismR21GM114853 · NIGMS · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2014 to 2015
$449k
NCI NIH HHS R21 CA182608NHLBI NIH HHS R01 HL125385NIGMS NIH HHS R01 GM118471NIGMS NIH HHS R21 GM114853
6 · The paper itself

Abstract

Coherent Raman scattering (CRS) microscopy is a high-speed vibrational imaging platform with the ability to visualize the chemical content of a living specimen by using molecular vibrational fingerprints. We review technical advances and biological applications of CRS microscopy. The basic theory of CRS and the state-of-the-art instrumentation of a CRS microscope are presented. We further summarize and compare the algorithms that are used to separate the Raman signal from the nonresonant background, to denoise a CRS image, and to decompose a hyperspectral CRS image into concentration maps of principal components. Important applications of single-frequency and hyperspectral CRS microscopy are highlighted. Potential directions of CRS microscopy are discussed.

Indexed as

biomedical imagingRaman scatteringvibrational spectroscopy

Identifiers

PMID27306307
PMCPMC5367927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.