Evidence map›Paper›PMID 27306206›Full record

ReviewGlycoconjugate journal2016

Iridoids are natural glycation inhibitors.

Brett J West, Shixin Deng, Akemi Uwaya, Fumiyuki Isami, Yumi Abe, Sho-Ichi Yamagishi, C Jarakae Jensen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Glycoconjugate journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Nutrients · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Medicines (Basel, Switzerland) · 2018
    Review
  7. Review
  8. Article
  9. Article
  10. Antioxidant activity against HPharmaceutical biology · 2017
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Brett J WestResearch and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT, 84003, USA. brett_west@morinda.com.
Shixin DengResearch and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT, 84003, USA.
Akemi UwayaResearch and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT, 84003, USA.
Fumiyuki IsamiResearch and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT, 84003, USA.
Yumi AbeAnti-Aging Medical Research Center and Glycation Stress Research Center, Doshisha University, Kyoto, Japan.
Sho-Ichi YamagishiKurume University School of Medicine, Kurume, Japan.
C Jarakae JensenResearch and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT, 84003, USA.
American Fork Hospital · USDoshisha University · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycation of amino acid residues in proteins leads to the eventual formation of advanced glycation end products (AGEs). AGE formation significantly influences human health and the aging process. AGE accumulation rates may be slowed by modifications to lifestyle or by pharmacological strategies. But the use of therapeutic drugs is not an appropriate means of controlling AGEs within the general population. However, phytochemical constituents in plant-based foods exhibit anti-glycation activities and may be more appropriate for general consumption. Among these phytochemicals are iridoids. The anti-AGE potential of iridoids has been demonstrated in vitro and in vivo, while also revealing possible mechanisms of action. Inclusion of iridoid food sources in the diet may be a useful component of strategies intended to mitigate AGE accumulation within the body.

Indexed as

AgingAnimalsGlycation End Products, AdvancedHumansIridoidsGlycation End Products, AdvancedIridoidsAdvanced glycation end productsDicarbonylsGlycationIridoid

Identifiers

PMID27306206
OpenAlexW2443864270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.