ArticleClinical and translational science2016
A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy.
Article in Clinical and translational science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Exposure of Bladder Cancer Cells to Blue Light (λ = 453 nm) in the Presence of Riboflavin Synergistically Enhances the Cytotoxic Efficiency of Gemcitabine.International journal of molecular sciences · 2024Article
- A metabolomic-based biomarker discovery study for predicting phototherapy duration for neonatal hyperbilirubinemia.Translational pediatrics · 2022Article
- Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia.Computational and structural biotechnology journal · 2022Article
- Pharmacometabolomics by NMR in Oncology: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Challenges of phototherapy for neonatal hyperbilirubinemia (Review).Experimental and therapeutic medicine · 2021Review
- Serum Metabolomic Profiles Associated With Untreated Metabolic Syndrome Patients in the Chinese Population.Clinical and translational science · 2020Observational
- Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.Clinical and translational science · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phototherapy has been widely used in treating neonatal jaundice, but detailed metabonomic profiles of neonatal jaundice patients and response to phototherapy have not been characterized. Our aim was to depict the serum metabolic characteristics of neonatal jaundice patients relative to controls and changes in response to phototherapy. A (1) H nuclear magnetic resonance (NMR)-based metabonomic approach was employed to study the metabolic profiling of serum from healthy infants (n = 25) and from infants with neonatal jaundice (n = 30) pre- and postphototherapy. The acquired data were processed by multivariate principal component analysis (PCA) and orthogonal partial least-squares-discriminant analysis (OPLS-DA). The PLS-DA and OPLS-DA model identified nine metabolites capable of distinguishing patients from controls. In addition, 28 metabolites such as β-glucose, α-glucose, valine, and pyruvate changed in response to phototherapy. This study offers useful information on metabolic disorders in neonatal jaundice patients and the effects of phototherapy on lipids, amino acid, and energy metabolism.
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