ArticleScientific reports2016
Clostridium perfringens α-Toxin Impairs Innate Immunity via Inhibition of Neutrophil Differentiation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Intestinal microbiome in necrotic enteritis infection of broiler and comparison of treatment alternatives.Tropical animal health and production · 2026Article
- Repurposing caspofungin as a small-molecule inhibitor of Clostridium perfringens α-toxin for treatment of gas gangrene.Communications medicine · 2026Article
- A rare but lethal hepatic infection: Emphysematous hepatitis - Case report and literature review.Hepatology forum · 2026Article
- Prevalence and antimicrobial resistance patterns ofOne health (Amsterdam, Netherlands) · 2025Article
- Sudden death due to enterotoxemia among Arabian camels (Open veterinary journal · 2024Article
- Overview of Bacterial Protein Toxins from Pathogenic Bacteria: Mode of Action and Insights into Evolution.Toxins · 2024Review
- Diagnostic and Management of Emphysematous Hepatitis with Emphasis on Biopathology.Microorganisms · 2023Article
- Review
- Intestinal inflammation and the microbiota: Beyond diversity.World journal of gastroenterology · 2022Article
- Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis.Frontiers in surgery · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Article
- Stress-Related Herpesvirus Reactivation in Badgers Can Result in Clostridium Proliferation.EcoHealth · 2021Article
- Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using aAnimals : an open access journal from MDPI · 2021Article
- Toll-Like Receptor 4 Protects AgainstFrontiers in cellular and infection microbiology · 2021Article
- Article
- Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene.Infection and immunity · 2019Article
- Histotoxic Clostridial Infections.Microbiology spectrum · 2019Article
- Inflammasome Activation Induced by Perfringolysin O ofFrontiers in microbiology · 2019Article
- Article
- Circular RNA expression profile of spleen in aFEBS open bio · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although granulopoiesis is accelerated to suppress bacteria during infection, some bacteria can still cause life-threatening infections, but the mechanism behind this remains unclear. In this study, we found that mature neutrophils in bone marrow cells (BMCs) were decreased in C. perfringens-infected mice and also after injection of virulence factor α-toxin. C. perfringens infection interfered with the replenishment of mature neutrophils in the peripheral circulation and the accumulation of neutrophils at C. perfringens-infected sites in an α-toxin-dependent manner. Measurements of bacterial colony-forming units in C. perfringens-infected muscle revealed that α-toxin inhibited a reduction in the load of C. perfringens. In vitro treatment of isolated BMCs with α-toxin (phospholipase C) revealed that α-toxin directly decreased mature neutrophils. α-Toxin did not influence the viability of isolated mature neutrophils, while simultaneous treatment of BMCs with granulocyte colony-stimulating factor attenuated the reduction of mature neutrophils by α-toxin. Together, our results illustrate that impairment of the innate immune system by the inhibition of neutrophil differentiation is crucial for the pathogenesis of C. perfringens to promote disease to a life-threatening infection, which provides new insight to understand how pathogenic bacteria evade the host immune system.
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