ArticleProceedings. Biological sciences2016
Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory in Caenorhabditis elegans.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 81 citations in OpenAlex.
- Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non-mammalian Models.Environmental toxicology · 2026Review
- Lowest Environmentally Relevant Concentrations of Ionic Silver in Picograms per Liter Impair Life History Traits and Population Growth ofJournal of xenobiotics · 2026Article
- Article
- Effects of Multiple Stressors, Pristine or Sulfidized Silver Nanomaterials, and a Pathogen on a Model Soil NematodeNanomaterials (Basel, Switzerland) · 2024Article
- Multigenerational exposure of Ag materials (nano and salt) in soil - environmental hazards inNanoscale advances · 2024Article
- Multigenerational Effects of Graphene Oxide Nanoparticles onInternational journal of molecular sciences · 2023Article
- Global DNA Adenine Methylation inInternational journal of molecular sciences · 2023Article
- Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors.Biosensors · 2022Review
- Insights on the Dynamics and Toxicity of Nanoparticles in Environmental Matrices.Bioinorganic chemistry and applications · 2022Review
- Epigenetic effects induced by silver nanoparticles in Caenorhabditis elegans after multigenerational exposure.The Science of the total environment · 2020Article
- Multigenerational Exposure to WCCo Nanomaterials-Epigenetics in the Soil InvertebrateNanomaterials (Basel, Switzerland) · 2020Article
- Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations.Microorganisms · 2020Review
- Caenorhabditis elegans as an emerging model system in environmental epigenetics.Environmental and molecular mutagenesis · 2018Review
- A Current Overview of the Biological and Cellular Effects of Nanosilver.International journal of molecular sciences · 2018Review
- Transgenerational interactions between pesticide exposure and warming in a vector mosquito.Evolutionary applications · 2018Article
- Multigenerational effects of copper nanomaterials (CuONMs) are different of those of CuClScientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects from multigenerational exposures to engineered nanoparticles (ENPs) in their pristine and transformed states are currently unknown despite such exposures being an increasingly common scenario in natural environments. Here, we examine how exposure over 10 generations affects the sensitivity of the nematode Caenorhabditis elegans to pristine and sulfidized Ag ENPs and AgNO3 We also include populations that were initially exposed over six generations but kept unexposed for subsequent four generations to allow recovery from exposure. Toxicity of the different silver forms decreased in the order AgNO3, Ag ENPs and Ag2S ENPs. Continuous exposure to Ag ENPs and AgNO3 caused pronounced sensitization (approx. 10-fold) in the F2 generation, which was sustained until F10. This sensitization was less pronounced for Ag2S ENP exposures, indicating different toxicity mechanisms. Subtle changes in size and lifespan were also measured. In the recovery populations, the sensitivity to Ag ENPs and AgNO3 resulting from the initial multigenerational exposure persisted. Their response sensitivity for all endpoints was most closely related to the last ancestral exposed generation (F5), rather than unexposed controls. The mechanisms of transgenerational transfer of sensitivity are probably organized through the epigenome, and we encourage others to investigate such effects as a priority for mechanistic toxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.