ArticleNature communications2016
Three-dimensional spatiotemporal focusing of holographic patterns.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed.
- Single-Pulse Femtosecond Laser 3D Multi-Foci Light-Field Engineering via Multi-Layer Noise Threshold Filtering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuronal ensembles in cortical function and disease.Physiological reviews · 2026Review
- Spatiotemporal control of ultrafast pulses in multimode optical fibers.Nature communications · 2025Article
- Three-dimensional scanless patterned illumination using time-multiplexed multiline temporal focusing for multicell manipulation with single-cell resolution.Journal of biomedical optics · 2025Article
- Article
- A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.bioRxiv : the preprint server for biology · 2025Article
- Near-infrared fluorogenic RNA for in vivo imaging and sensing.Nature communications · 2025Article
- Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus.PLoS biology · 2024Article
- Closed-loop experiments and brain machine interfaces with multiphoton microscopy.Neurophotonics · 2024Review
- Multicolor two-photon light-patterning microscope exploiting the spatio-temporal properties of a fiber bundle.Biomedical optics express · 2024Article
- Wavefront shaping improves the transparency of the scattering media: a review.Journal of biomedical optics · 2024Review
- Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Descanned fast light targeting (deFLiT) two-photon optogenetics.Biomedical optics express · 2023Article
- Bayesian target optimisation for high-precision holographic optogenetics.bioRxiv : the preprint server for biology · 2023Article
- Single celliScience · 2023Article
- Dynamic ultraviolet harmonic beam pattern control by programmable spatial wavefront modulation of near-infrared fundamental beam.Nanophotonics (Berlin, Germany) · 2023Article
- Ultrafast light targeting for high-throughput precise control of neuronal networks.Nature communications · 2023Article
- Scanless two-photon voltage imaging.Research square · 2023Article
- WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells.Science advances · 2022Article
- Light-field microscopy with temporal focusing multiphoton illumination for scanless volumetric bioimaging.Biomedical optics express · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Two-photon excitation with temporally focused pulses can be combined with phase-modulation approaches, such as computer-generated holography and generalized phase contrast, to efficiently distribute light into two-dimensional, axially confined, user-defined shapes. Adding lens-phase modulations to 2D-phase holograms enables remote axial pattern displacement as well as simultaneous pattern generation in multiple distinct planes. However, the axial confinement linearly degrades with lateral shape area in previous reports where axially shifted holographic shapes were not temporally focused. Here we report an optical system using two spatial light modulators to independently control transverse- and axial-target light distribution. This approach enables simultaneous axial translation of single or multiple spatiotemporally focused patterns across the sample volume while achieving the axial confinement of temporal focusing. We use the system's capability to photoconvert tens of Kaede-expressing neurons with single-cell resolution in live zebrafish larvae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.