Evidence map›Paper›PMID 27305985›Full record

ArticleJournal of human genetics2016

Evaluation of polygenic risks for narcolepsy and essential hypersomnia.

Maria Yamasaki, Taku Miyagawa, Hiromi Toyoda, Seik-Soon Khor, Xiaoxi Liu, Hitoshi Kuwabara, Yukiko Kano, Takafumi Shimada, Toshiro Sugiyama, Hisami Nishida and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genetics of narcolepsy.Human genome variation · 2019
    Review
  10. Strong Association of theJournal of the American Society of Nephrology : JASN · 2018
    Article
  11. Review
  12. Article
  13. New developments in the management of narcolepsy.Nature and science of sleep · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 1 country.

Maria YamasakiDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Taku MiyagawaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiromi ToyodaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Seik-Soon KhorDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Xiaoxi LiuLaboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Kanagawa, Japan.
Hitoshi KuwabaraDepartment of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yukiko KanoDepartment of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takafumi ShimadaDivision for Counseling and Support, The University of Tokyo, Tokyo, Japan.
Toshiro SugiyamaDepartment of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Hisami NishidaAsunaro Hospital for Child and Adolescent Psychiatry, Mie, Japan.
Nagisa SugayaDepartment of Epidemiology and Public Health, Yokohama City University Graduate school of Medicine, Kanagawa, Japan.
Mamoru TochigiTeikyo University Hospital, Tokyo, Japan.
Takeshi OtowaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuji OkazakiTokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
Hisanobu KaiyaPanic Disorder Research Center, Warakukai Med Corp, Tokyo, Japan.
Yoshiya KawamuraDepartment of Psychiatry, Shonan Kamakura General Hospital, Kanagawa, Japan.
Akinori MiyashitaDepartment of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan.
Ryozo KuwanoDepartment of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hisashi TaniiDepartment of Psychiatry, Graduate School of Medicine, Mie University, Mie, Japan.
Tsukasa SasakiDepartment of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
Yutaka HondaJapan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
Makoto HondaSleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPNiigata University · JPHamamatsu University School of Medicine · JPJapan Graduate School of Education University · JPMie University · JPRIKEN Center for Integrative Medical Sciences · JPShonan Kamakura General Hospital · JPTeikyo University Hospital · JPTokyo Metropolitan Institute of Medical Science · JPTokyo Metropolitan Matsuzawa Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, narcolepsy is a sleep disorder that is characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities. Essential hypersomnia (EHS) is another type of sleep disorder that is characterized by excessive daytime sleepiness without cataplexy. A human leukocyte antigen (HLA) class II allele, HLA-DQB1*06:02, is a major genetic factor for narcolepsy. Almost all narcoleptic patients are carriers of this HLA allele, while 30-50% of EHS patients and 12% of all healthy individuals in Japan carry this allele. The pathogenesis of narcolepsy and EHS is thought to be partially shared. To evaluate the contribution of common single-nucleotide polymorphisms (SNPs) to narcolepsy onset and to assess the common genetic background of narcolepsy and EHS, we conducted a polygenic analysis that included 393 narcoleptic patients, 38 EHS patients with HLA-DQB1*06:02, 119 EHS patients without HLA-DQB1*06:02 and 1582 healthy individuals. We also included 376 individuals with panic disorder and 213 individuals with autism to confirm whether the results were biased. Polygenic risks in narcolepsy were estimated to explain 58.1% (P

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseMultifactorial InheritanceAllelesComparative Genomic HybridizationDisorders of Excessive SomnolenceGenotypeHLA-DQ beta-ChainsHumansNarcolepsyPhenotypePolymorphism, Single NucleotideRiskHLA-DQB1 antigenHLA-DQ beta-Chains

Identifiers

PMID27305985
OpenAlexW2441624413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.