ArticleScientific reports2016
Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition.The Journal of physiology · 2026Review
- Sitagliptin as a therapeutic approach for social anxiety disorder: the role of DPP4 and NPY in modulating social fear and comorbid depressive-like behavior in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Molecular origin and biological effects of exercise mimetics.Journal of exercise science and fitness · 2024Review
- Acute gut inflammation reduces neural activity and spine maturity in hippocampus but not basolateral amygdala.Scientific reports · 2022Article
- The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota.Tissue barriers · 2022Article
- Digging Deeper: Advancements in Visualization of Inhibitory Synapses in Neurodegenerative Disorders.International journal of molecular sciences · 2021Review
- Exercise mimetics: harnessing the therapeutic effects of physical activity.Nature reviews. Drug discovery · 2021Review
- Behavior Testing in Rodents: Highlighting Potential Confounds Affecting Variability and Reproducibility.Brain sciences · 2021Review
- Social housing enhances acquisition of task set independently of environmental enrichment: A longitudinal study in the Barnes maze.Learning & behavior · 2020Article
- Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect.Frontiers in immunology · 2020Review
- TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition.PLoS genetics · 2019Article
- Coping with Stress During Aging: The Importance of a Resilient Brain.Current neuropharmacology · 2018Review
- Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.Translational psychiatry · 2018Article
- Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons.PloS one · 2018Article
- Post-weaning Environmental Enrichment in Male CD-1 Mice: Impact on Social Behaviors, Corticosterone Levels and Prefrontal Cytokine Expression in Adulthood.Frontiers in behavioral neuroscience · 2018Article
- Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling.Current biology : CB · 2017Article
- Endogenously Released Neuropeptide Y Suppresses Hippocampal Short-Term Facilitation and Is Impaired by Stress-Induced Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Environmental enrichment (EE) refers to the provision of a complex and stimulating housing condition which improves well-being, behaviour and brain function of laboratory animals. The mechanisms behind these beneficial effects of EE are only partially understood. In the current report, we describe a link between EE and neuropeptide Y (NPY), based on findings from NPY knockout (KO) mice exposed to EE. Relative to EE-housed wildtype (WT) animals, NPY KO mice displayed altered behaviour as well as molecular and morphological changes in amygdala and hippocampus. Exposure of WT mice to EE reduced anxiety and decreased central glucocorticoid receptor expression, effects which were absent in NPY KO mice. In addition, NPY deletion altered the preference of EE items, and EE-housed NPY KO mice responded to stress with exaggerated hyperthermia, displayed impaired spatial memory, had higher hippocampal brain-derived neurotrophic factor mRNA levels and altered hippocampal synaptic plasticity, effects which were not seen in WT mice. Accordingly, these findings suggest that NPY contributes to the anxiolytic effect of EE and that NPY deletion reverses the beneficial effects of EE into a negative experience. The NPY system could thus be a target for "enviromimetics", therapeutics which reproduce the beneficial effects of enhanced environmental stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.