ArticleJournal of biomedical nanotechnology2016
Size-Dependent Mechanism of Intracellular Localization and Cytotoxicity of Mono-Disperse Spherical Mesoporous Nano- and Micron-Bioactive Glass Particles.
Article in Journal of biomedical nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- The mechanism of 45S5 bioactive glass-mediated, cell-type-specific death of bone tumor cells.Cell death discovery · 2026Article
- Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature.Advanced healthcare materials · 2026Review
- Targeting Bone Tumours with 45S5 Bioactive Glass.International journal of molecular sciences · 2024Article
- Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications.Bioactive materials · 2024Review
- The potential impacts of micro-and-nano plastics on various organ systems in humans.EBioMedicine · 2024Review
- Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function.Theranostics · 2023Article
- Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes.Journal of nanobiotechnology · 2022Article
- Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects.Advances in nutrition (Bethesda, Md.) · 2022Review
- The Antibiofilm Activity and Mechanism of Nanosilver- and Nanozinc-Incorporated Mesoporous Calcium-Silicate Nanoparticles.International journal of nanomedicine · 2020Article
- Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities.Materials today. Bio · 2020Article
- Collagen and fibronectin surface modification of nanoporous anodic alumina and macroporous silicon for endothelial cell cultures.Journal of biological engineering · 2018Article
- Cytotoxicity of Titanate-Calcium Complexes to MC3T3 Osteoblast-Like Cells.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Mono-disperse spherical mesoporous nano- and micro- bioactive glass particles (NMBGs) can find potential use in bone tissue engineering. However, their size-dependent interaction with osteoblasts has never been studied. Herein, the proliferation, morphology, cytoskeleton organization and apoptosis of MC3T3-E1 osteoblasts are studied in response to the NMBGs with varying sizes (from 61 to 1085 nm) at different concentrations. Generally, smaller NMBGs at a lower dose show weaker cytotoxicity compared to the larger particles and higher doses, arising from a novel size-dependent mechanisrm of intracellular localization of NMBGs observed by electron and confocal microscopy. Specifically, NMBGs pass through perinuclear membrane of the cells to initiate endocytosis. Once internalized, the sizes of NMBGs are found to play a significant role in determining their intracellular localization. When the NMBGs are smaller than 174 nm, they are transported via the lysosomal pathway and phagocytized in lysosomes, resulting in little cytotoxicity at later time points. On the contrary, larger NMBGs (over 174 nm) escape from the lysosomes after endocytosis, and are localized inside the intra-cytoplasmic vacuoles or randomly in the cytoplasm of cells. Their lysosomal escape may damage the lysosomes, inducing cell apoptosis and thus the greater cytotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.