ArticleAdvanced materials (Deerfield Beach, Fla.)2016
Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche.
Article in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
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Who cites it
33 citing papers in PubMed.
- Generating protein hydrogels with customizable stress relaxation behavior via deep learning-driven entanglement design.Nature communications · 2026Article
- Adaptable sliding hydrogels enable pericellular pocket formation while enhancing MSC chondrogenesis and survival in 3D.Bioactive materials · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Microscale Mechanical Cues in Hydrogels: Engineering Strategies to Modulate Cell Fates in Three Dimensions.Cell biomaterials · 2026Article
- Synthesis of hydrazine-functionalized Polyrotaxane and formation of adaptable sliding hydrogels.MethodsX · 2026Article
- A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction.Nature communications · 2025Article
- Advanced cell-adaptable hydrogels for bioprinting.Bioactive materials · 2025Review
- Tuning local matrix compliance accelerates mesenchymal stem cell chondrogenesis in 3D sliding hydrogels.Biomaterials · 2025Article
- Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations.Advanced functional materials · 2025Article
- Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro.Advanced healthcare materials · 2025Article
- Cell tumbling enhances stem cell differentiation in hydrogels via nuclear mechanotransduction.Nature materials · 2025Article
- Sliding Hydrogels Reveal the Modulation of Mechanosensing Attenuates the Inflammatory Phenotype of Osteoarthritic Chondrocytes in 3D.Journal of biomedical materials research. Part A · 2025Article
- Chemical strategies to engineer hydrogels for cell culture.Nature reviews. Chemistry · 2022Review
- Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs.Matter · 2022Article
- 3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Adaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells.Bioactive materials · 2021Review
- Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells.Regenerative biomaterials · 2021Article
- Mechanosensitive regulation of stanniocalcin-1 by zyxin and actin-myosin in human mesenchymal stromal cells.Stem cells (Dayton, Ohio) · 2020Article
- Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation.Biomacromolecules · 2020Article
- Regulation of Stem Cell Function in an Engineered Vocal Fold-Mimetic Environment.Regenerative engineering and translational medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this sliding hydrogel allows stem cells to reorganize the surrounding ligands and change their morphology in 3D. Without changing matrix stiffness, sliding hydrogels support efficient stem cell differentiation toward multiple lineages including adipogenesis, chondrogenesis, and osteogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.