ArticleAngewandte Chemie (International ed. in English)2016
Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C-H Bond Addition Cascade.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 169 citations in OpenAlex.
- Visible Light Promoted Alkenyl C-H Bond Addition to Dienes and Aldehydes for the Synthesis of Frameworks Relevant to Polyketide Natural Products.ACS catalysis · 2026Article
- C-H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines withACS catalysis · 2024Article
- C-H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity.Chemical Society reviews · 2022Review
- Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)-Catalyzed Sequential C-H Bond Addition to 1,3-Enynes and Aldehydes.Angewandte Chemie (International ed. in English) · 2022Article
- Three-Component Coupling of Arenes, Ethylene, and Alkynes Catalyzed by a Cationic Bis(phosphine) Cobalt Complex: Intercepting Metallacyclopentenes for C-H Functionalization.Journal of the American Chemical Society · 2022Article
- Synthesis of α-Branched Amines by Three- and Four-Component C-H Functionalization Employing a Readily Diversifiable Hydrazone Directing Group.Organic letters · 2021Article
- Dirhodium(ii)-catalysed cycloisomerization of azaenyne: rapid assembly of centrally and axially chiral isoindazole frameworks.Chemical science · 2021Article
- Direct Preparation ofThe Journal of organic chemistry · 2021Article
- Synthesis of Nitrile Bearing Acyclic Quaternary Centers through Co(III)-Catalyzed Sequential C-H Bond Addition to Dienes and N-Cyanosuccinimide.Angewandte Chemie (International ed. in English) · 2021Article
- Cp*Co(III)-Catalyzed C-H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool.ACS omega · 2020Review
- Cobalt(III)-Catalyzed Diastereoselective Three-Component C-H Bond Addition to Butadiene and Activated Ketones.Synthesis · 2020Article
- Asymmetric Mannich reactions of (Beilstein journal of organic chemistry · 2020Article
- Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoAngewandte Chemie (International ed. in English) · 2019Article
- A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.Chemical Society reviews · 2018Review
- Thiocarbonyl-enabled ferrocene C-H nitrogenation by cobalt(III) catalysis: thermal and mechanochemical.Beilstein journal of organic chemistry · 2018Article
- Selective and synergistic cobalt(III)-catalyzed three-component C-H bond addition to dienes and aldehydes.Nature catalysis · 2018Article
- Hydroarylations by cobalt-catalyzed C-H activation.Beilstein journal of organic chemistry · 2018Review
- Convergent Synthesis ofIsrael journal of chemistry · 2017Article
- Co(III)-Catalyzed C-H Activation: A Site-Selective Conjugate Addition of Maleimide to Indole at the C-2 Position.ACS omega · 2017Article
- A Convergent Synthesis of Functionalized Alkenyl Halides through Cobalt(III)-Catalyzed Three-Component C-H Bond Addition.Angewandte Chemie (International ed. in English) · 2017Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
A highly stereoselective three-component C(sp(2) )-H bond addition across alkene and polarized π-bonds is reported for which Co(III) catalysis was shown to be much more effective than Rh(III) . The reaction proceeds at ambient temperature with both aryl and alkyl enones employed as efficient coupling partners. Moreover, the reaction exhibits extremely broad scope with respect to the aldehyde input; electron rich and poor aromatic, alkenyl, and branched and unbranched alkyl aldehydes all couple in good yield and with high diastereoselectivity. Multiple directing groups participate in this transformation, including pyrazole, pyridine, and imine functional groups. Both aromatic and alkenyl C(sp(2) )-H bonds undergo the three-component addition cascade, and the alkenyl addition product can readily be converted into diastereomerically pure five-membered lactones. Additionally, the first asymmetric reactions with Co(III) -catalyzed C-H functionalization are demonstrated with three-component C-H bond addition cascades employing N-tert-butanesulfinyl imines. These examples represent the first transition metal catalyzed C-H bond additions to N-tert-butanesulfinyl imines, which are versatile and extensively used intermediates for the asymmetric synthesis of amines.
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