ArticlePloS one2016
Predictors and Implications of Early Clinical Stability in Patients Hospitalized for Moderately Severe Community-Acquired Pneumonia.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.American journal of respiratory and critical care medicine · 2019Guideline
- Factors Associated With Treatment Failure in Moderately Severe Community-Acquired Pneumonia: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2021Trial
- A study on the influencing factors of early clinical stability in patients with acute exacerbation of chronic obstructive pulmonary disease complicated by pneumonia.Journal of thoracic disease · 2025Article
- Reassessing Halm's clinical stability criteria in community-acquired pneumonia management.The European respiratory journal · 2024Article
- Multi-Modal Data Analysis for Pneumonia Status Prediction Using Deep Learning (MDA-PSP).Diagnostics (Basel, Switzerland) · 2022Article
- COVID-19 multidisciplinary high dependency unit: the Milan model.Respiratory research · 2020Review
- Biomarkers in Pneumonia-Beyond Procalcitonin.International journal of molecular sciences · 2019Review
- Time to Clinical Stability Among Pediatric Patients With Severe Pneumonia: Southwest Ethiopia: Prospective Follow-Up Study.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of early response to treatment is crucial for the management of community-acquired pneumonia (CAP).
objectiveTo describe the predictors and the outcomes of early clinical stability.
methodsWe did a secondary analysis of a multicentre randomized controlled trial on CAP treatment in which 580 patients hospitalized for moderately severe CAP were included. The association between demographic, clinical and biological variables available at inclusion and early clinical stability (stabilization of vital signs within 72 hours with predetermined cut-offs) was assessed by multivariate logistic regression. The association between early clinical stability and mortality, severe adverse events, and length of stay was also tested.
resultsYounger age (OR 0.98, 95% CI 0.96-0.99), lower platelet count (OR per 10 G/L increment 0.96, 95% CI 0.94-0.98), lower respiratory rate (OR 0.94, 95% CI 0.90-0.97), absence of hypoxemia (OR 0.58, 95% CI 0.40-0.85), lower numbers of co-morbid conditions (OR 0.82, 95% CI 0.69-0.98) and signs or symptoms (OR 0.78, 95% CI 0.68-0.90) were significantly associated with early clinical stability. Patients with early clinical stability had lower 90-days mortality (3.4% vs. 11.9%, p<0.001), fewer admissions to the intensive care unit (2.7% vs. 8.0%, p = 0.005) and a shorter length of stay (6.0 days, IQR 4.0-10.0 vs. 10.0 days, IQR 7.0-15.0, p<0.001).
conclusionsPatients with younger age, less co-morbidity, fewer signs or symptoms, less respiratory compromise, and a lower platelet count are more likely to reach early clinical stability. Patients without early clinical stability have a worse prognosis and warrant close scrutiny.
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