ArticlePLoS computational biology2016
Adaptive Spike Threshold Enables Robust and Temporally Precise Neuronal Encoding.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Designer indicators for two-photon recording of subthreshold voltage dynamics.Nature methods · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.bioRxiv : the preprint server for biology · 2026Article
- Bifurcation of spiking oscillations from a center in resonate-and-fire neurons.Biological cybernetics · 2026Article
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Wobble board instability enhances proactive postural control.Chaos, solitons, and fractals · 2025Article
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Neural heterogeneity as a unifying mechanism for efficient learning in spiking neural networks.Frontiers in computational neuroscience · 2025Article
- The tuning of tuning: How adaptation influences single cell information transfer.PLoS computational biology · 2024Article
- Short-term neuronal and synaptic plasticity act in synergy for deviance detection in spiking networks.PLoS computational biology · 2023Article
- Cortical Representation of Touch in Silico.Neuroinformatics · 2022Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neural heterogeneity promotes robust learning.Nature communications · 2021Article
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spike threshold adaptation diversifies neuronal operating modes in the auditory brain stem.Journal of neurophysiology · 2019Article
- A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.GigaScience · 2018Article
- State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures.Scientific reports · 2018Article
- Spike threshold dynamics in spinal motoneurons during scratching and swimming.The Journal of physiology · 2017Article
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4 authors.
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Abstract
Neural processing rests on the intracellular transformation of information as synaptic inputs are translated into action potentials. This transformation is governed by the spike threshold, which depends on the history of the membrane potential on many temporal scales. While the adaptation of the threshold after spiking activity has been addressed before both theoretically and experimentally, it has only recently been demonstrated that the subthreshold membrane state also influences the effective spike threshold. The consequences for neural computation are not well understood yet. We address this question here using neural simulations and whole cell intracellular recordings in combination with information theoretic analysis. We show that an adaptive spike threshold leads to better stimulus discrimination for tight input correlations than would be achieved otherwise, independent from whether the stimulus is encoded in the rate or pattern of action potentials. The time scales of input selectivity are jointly governed by membrane and threshold dynamics. Encoding information using adaptive thresholds further ensures robust information transmission across cortical states i.e. decoding from different states is less state dependent in the adaptive threshold case, if the decoding is performed in reference to the timing of the population response. Results from in vitro neural recordings were consistent with simulations from adaptive threshold neurons. In summary, the adaptive spike threshold reduces information loss during intracellular information transfer, improves stimulus discriminability and ensures robust decoding across membrane states in a regime of highly correlated inputs, similar to those seen in sensory nuclei during the encoding of sensory information.
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