ArticlePloS one2016
Three-Dimensional Reflectance Traction Microscopy.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.Scientific reports · 2021Article
- Engineering approaches to studying cancer cell migration in three-dimensional environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy.Scientific reports · 2019Article
- Microscale Interrogation of 3D Tissue Mechanics.Frontiers in bioengineering and biotechnology · 2019Review
- Stress-induced plasticity of dynamic collagen networks.Nature communications · 2017Article
- Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.Cellular and molecular life sciences : CMLS · 2017Review
- Probing three-dimensional collective cancer invasion with DIGME.Cancer convergence · 2017Article
- Traction Force Microscopy for Noninvasive Imaging of Cell Forces.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells in three-dimensional (3D) environments exhibit very different biochemical and biophysical phenotypes compared to the behavior of cells in two-dimensional (2D) environments. As an important biomechanical measurement, 2D traction force microscopy can not be directly extended into 3D cases. In order to quantitatively characterize the contraction field, we have developed 3D reflectance traction microscopy which combines confocal reflection imaging and partial volume correlation postprocessing. We have measured the deformation field of collagen gel under controlled mechanical stress. We have also characterized the deformation field generated by invasive breast cancer cells of different morphologies in 3D collagen matrix. In contrast to employ dispersed tracing particles or fluorescently-tagged matrix proteins, our methods provide a label-free, computationally effective strategy to study the cell mechanics in native 3D extracellular matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.