SynthesisOncotarget2016
Systematic analyses and comprehensive field synopsis of genetic association studies in hepatocellular carcinoma.
Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- Heparan sulfate chains in hepatocellular carcinoma.Gastroenterology report · 2025Review
- Research on the effects of rs1800566 C/T polymorphism of NAD(P)H quinone oxidoreductase 1 gene on cancer risk involves analysis of 43,736 cancer cases and 56,173 controls.Frontiers in oncology · 2022Article
- Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response.Journal of immunology research · 2019Article
- Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing.Disease models & mechanisms · 2018Article
- Genetic susceptibility of eight nonsynonymous polymorphisms in HLA-DRB1 gene to hepatocellular carcinoma in Han Chinese.Oncotarget · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignancy in the world. In order to comprehensively examine the association between genetic variants and risk of HCC, a systematic literature search and meta-analyses of the evidences have been performed. With the data from 301 articles, we conducted meta-analyses for 69 polymorphisms involving 46 distinct genes. The result showed that 31 polymorphisms in 25 genes are significantly associated with HCC risk. Cumulative epidemiological evidence for a significant association with HCC risk was graded strong for one polymorphism (NQO1 rs1800566). Furthermore, we provided a database to integrate and analyze the association of genetic variants and HCC risk. To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis of genetic association with HCC risk. We have provided a useful resource and platform for investigators to explore the association of sequence polymorphisms and HCC risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.