ArticlePediatric research2016
Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty.Journal of endocrinological investigation · 2025Article
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Study ofChildren (Basel, Switzerland) · 2024Article
- The Role of SNPs in the Pathogenesis of Idiopathic Central Precocious Puberty in Girls.Children (Basel, Switzerland) · 2023Review
- Genetic factors in precocious puberty.Clinical and experimental pediatrics · 2022Article
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- Association of LIN28B polymorphisms with chronic hepatitis B virus infection.Virology journal · 2020Article
- Article
- Genetics of pubertal timing.Current opinion in pediatrics · 2018Review
- Association between MKRN3 and LIN28B polymorphisms and precocious puberty.BMC genetics · 2018Article
- Gender-dependent association between sleep duration and overweight incidence in CHINESE school children: a national follow-up study.BMC public health · 2018Article
- Precocious Puberty and the Lin28/Let7 Pathway: The Therapeutic Effect of the Nourishing "Yin" and Purging "Fire" Traditional Chinese Medicine Mixture in a Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2018Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundGenome-wide association studies have identified rs314276, rs314263, rs7759938, and rs314280 in or near the LIN28B gene as associated with age at menarche. To date, the effect of polymorphisms in this gene on idiopathic central precocious puberty (ICPP) in Chinese girls have not been reported. The aim of this study was to evaluate the association of the four loci with ICPP in Chinese girls.
methodsIn this study, we conducted a case-control study including 502 girls with ICPP and 489 controls. Four single-nucleotide polymorphisms (SNPs) were genotyped in both groups using an improved multiplex ligation detection reaction (iMLDR) technique.
resultsOf the four SNPs of the LIN28B analyzed, three SNPs, rs314276, rs7759938, and rs314280, were associated with ICPP risk at P < 0.05. The association of rs314276, however, was no longer significant after adjustment for multiple testing. Compared with rs7759938 TT or TC genotype, decreased ICPP risk was associated with CC (OR = 0.527, 95% CI: 0.329-0.843) genotype (P = 0.008). Compared with rs314280 GG or GA genotype, decreased ICPP risk was associated with minor allele carrier (AA) genotype (OR = 0.538, 95% CI: 0.337-0.858, P = 0.009). The two identified variants showed the same association signals for ICPP.
conclusionIn conclusion, common genetic variations (rs7759938 and rs314280) of LIN28B may contribute to ICPP susceptibility in Chinese girls.
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