ArticleFrontiers in endocrinology2016
Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations.
Article in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Prevalence of nephropathy among patients with diabetes mellitus in Africa: a systematic review and meta-analysis.Frontiers in clinical diabetes and healthcare · 2025Pooled it
- Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review.BMJ open · 2018Pooled it
- Increasing burden of lower extremity peripheral arterial disease in Sub-Saharan Africa, 1990-2021 - results from the global burden of disease study 2021.American heart journal plus : cardiology research and practice · 2026Article
- Hypertension outcomes in a fragile setting: predictors of blood pressure reduction and control in the Central African Republic.Frontiers in public health · 2025Article
- Kidney damage and associated risk factors in the rural Eastern Cape, South Africa: A cross-sectional study.PloS one · 2024Observational
- Obesity and CKD in Sub-Saharan Africa: A Narrative Review.Kidney medicine · 2022Review
- Ultrasonographic Renal Dimensions Amongst Adult Nigerian Diabetics: Correlation with Clinical, Anthropometric and Metabolic Risk Factors.African journal of biomedical research : AJBR · 2020Article
- Type 2 diabetes complications and comorbidity in Sub-Saharan Africans.EClinicalMedicine · 2019Article
- Article
- The Global Epidemiology of Diabetes and Kidney Disease.Advances in chronic kidney disease · 2018Review
- Genetically proxied inhibition of kidney function pathways and increased risk of type 2 diabetes in Africans: A Mendelian randomization study.Science progressArticle
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundDiabetes is a leading risk factor for impaired kidney function, an indicator of chronic kidney disease. The aim of this study was to examine the association between type 2 diabetes (T2D) and impaired kidney function among adults in sub-Saharan Africa (SSA).
methodsParticipants were enrolled from Ghana, Kenya, and Nigeria. Impaired kidney function was based on an estimated glomerular filtration rate <60 ml/min/1.73 m(2). Using logistic regression models, we conducted case-control analyses to estimate the multivariate-adjusted association of T2D and kidney function.
resultsWe used data from 4815 participants for whom the mean (SD) age was 48 (15) years, 41% were male and 46% had T2D. Those with T2D were more likely to have impaired kidney function [13.4% (95% CI: 11.9-14.7)] compared to those without T2D [4.8% (95% CI: 4.0-5.6)], p-value <0.001. The multivariate odds ratio of impaired kidney function among those with type 2 diabetes was 1.50 (95% CI: 1.17-1.91) p-value = 0.001, compared to those without T2D. Also, individuals with T2D who were at least 60 years old, obese, hypertensive or dyslipidemic were more likely to have impaired kidney function compared to those without T2D.
conclusionT2D was associated with 50% increased risk of impaired kidney function in this sample of adults from SSA. Interventions targeted at prevention, early diagnosis, and management of T2D are likely to reduce the burden of kidney disease in SSA.
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