Evidence map›Paper›PMID 27303362›Full record

ArticleFrontiers in neurology2016

Unique Exercise Lactate Profile in Muscle Phosphofructokinase Deficiency (Tarui Disease); Difference Compared with McArdle Disease.

Päivi Piirilä, Minna E Similä, Johanna Palmio, Tomi Wuorimaa, Emil Ylikallio, Satu Sandell, Petri Haapalahti, Lasse Uotila, Henna Tyynismaa, Bjarne Udd and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Päivi PiiriläUnit of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Hospital and University of Helsinki , Helsinki , Finland.
Minna E SimiläDepartment of Clinical Nutrition Therapy, Helsinki University Central Hospital , Helsinki , Finland.
Johanna PalmioNeuromuscular Research Center, Tampere University Hospital, University of Tampere , Tampere , Finland.
Tomi WuorimaaUnit of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Hospital and University of Helsinki , Helsinki , Finland.
Emil YlikallioResearch Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki , Helsinki , Finland.
Satu SandellNeuromuscular Research Center, Tampere University Hospital, University of Tampere, Tampere, Finland; Department of Neurology, Seinäjoki Central Hospital, Seinäjoki, Finland; Department of Neurology, Tampere University Hospital, Tampere University, Tampere, Finland.
Petri HaapalahtiUnit of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Hospital and University of Helsinki , Helsinki , Finland.
Lasse UotilaLaboratory of Clinical Chemistry, HUSLAB, Helsinki University Hospital , Helsinki , Finland.
Henna TyynismaaResearch Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.
Bjarne UddNeuromuscular Research Center, Tampere University Hospital, University of Tampere , Tampere , Finland.
Mari AuranenResearch Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Clinical Neurosciences, Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIHelsinki University Hospital · FITampere University · FISeinäjoki University of Applied Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGlycogen storage disease V (GSDV, McArdle disease) and GSDVII (Tarui disease) are the most common of the rare disorders of glycogen metabolism. Both are associated with low lactate levels on exercise. Our aim was to find out whether lactate response associated with exercise testing could distinguish between these disorders.

methodsTwo siblings with Tarui disease, two patients with McArdle disease and eight healthy controls were tested on spiroergometric exercise tests with follow-up of venous lactate and ammonia.

resultsA late increase of lactate about three times the basal level was seen 10-30 min after exercise in patients with Tarui disease being higher than in McArdle disease and lower than in the controls. Ammonia was increased in Tarui disease. DISCUSSION: Our results suggest that follow-up of lactate associated with exercise testing can be utilized in diagnostics to distinguish between different GSD diseases.

Indexed as

ammonialactateMcArdle diseasemuscle metabolismmuscle phosphofructokinasepentose phosphate pathwayspiroergometryTarui disease

Identifiers

PMID27303362
PMCPMC4885106
OpenAlexW2441929972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.