ArticleFrontiers in neuroanatomy2016
Parametric Probability Distribution Functions for Axon Diameters of Corpus Callosum.
Article in Frontiers in neuroanatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Axon Diameter Mapping in the Living Human Brain with Ultra-High-Gradient Diffusion MRI at 500 mT/m Gradient Strength.Human brain mapping · 2026Article
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- MRI-scale histology validates spatial sensitivity of in-vivo MRI-based axon radius estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Toward understanding the brain tissue behavior due to preconditioning: an experimental study and RVE approach.Frontiers in bioengineering and biotechnology · 2024Article
- Histology-informed multiscale modeling of human brain white matter.Scientific reports · 2023Article
- CACTUS: a computational framework for generating realistic white matter microstructure substrates.Frontiers in neuroinformatics · 2023Article
- Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology.Frontiers in neuroscience · 2023Article
- Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics.Communications biology · 2022Article
- Article
- Cuprizone Intoxication Results in Myelin Vacuole Formation.Frontiers in cellular neuroscience · 2022Article
- The variability of MR axon radii estimates in the human white matter.Human brain mapping · 2021Article
- The sensitivity of diffusion MRI to microstructural properties and experimental factors.Journal of neuroscience methods · 2021Review
- Tutorial: a computational framework for the design and optimization of peripheral neural interfaces.Nature protocols · 2020Review
- Article
- Article
- Along-axon diameter variation and axonal orientation dispersion revealed with 3D electron microscopy: implications for quantifying brain white matter microstructure with histology and diffusion MRI.Brain structure & function · 2019Article
- AxonPacking: An Open-Source Software to Simulate Arrangements of Axons in White Matter.Frontiers in neuroinformatics · 2017Article
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6 authors.
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Abstract
Axon diameter is an important neuroanatomical characteristic of the nervous system that alters in the course of neurological disorders such as multiple sclerosis. Axon diameters vary, even within a fiber bundle, and are not normally distributed. An accurate distribution function is therefore beneficial, either to describe axon diameters that are obtained from a direct measurement technique (e.g., microscopy), or to infer them indirectly (e.g., using diffusion-weighted MRI). The gamma distribution is a common choice for this purpose (particularly for the inferential approach) because it resembles the distribution profile of measured axon diameters which has been consistently shown to be non-negative and right-skewed. In this study we compared a wide range of parametric probability distribution functions against empirical data obtained from electron microscopy images. We observed that the gamma distribution fails to accurately describe the main characteristics of the axon diameter distribution, such as location and scale of the mode and the profile of distribution tails. We also found that the generalized extreme value distribution consistently fitted the measured distribution better than other distribution functions. This suggests that there may be distinct subpopulations of axons in the corpus callosum, each with their own distribution profiles. In addition, we observed that several other distributions outperformed the gamma distribution, yet had the same number of unknown parameters; these were the inverse Gaussian, log normal, log logistic and Birnbaum-Saunders distributions.
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