Prevalence and Resolution of Lupus Anticoagulant in Children.

Chandra Kallanagowdar, Aman Chauhan, Mora V Puertolas, Rajasekharan Warrier

Open access · greenAbstract read

In one paragraph

Article in Ochsner journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.2field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Chandra KallanagowdarDepartment of Hematology/Oncology, Louisiana State University Health Sciences Center/Children's Hospital, New Orleans, LA.

Aman ChauhanDepartment of Pediatrics, Louisiana State University Health Services Center/Children's Hospital, New Orleans, LA.

Mora V PuertolasThe University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Rajasekharan WarrierThe University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA ; Department of Pediatric Hematology/Oncology, Ochsner Clinic Foundation, New Orleans, LA.

Louisiana State University · USLouisiana State University Health Sciences Center New Orleans · USOchsner Medical Center · USThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLupus anticoagulant (LA) is an autoantibody that inhibits phospholipid-dependent reactions. Studies on the incidence and prevalence of LA in the pediatric population are lacking. The objective of our study was to determine the incidence and potential risk of complications of LA in children presenting with abnormal partial thromboplastin time (PTT). Our secondary objective was to identify signs, symptoms, and medical history associated with the presence of LA as documented in the literature. We focused on the correlation between signs of LA in the form of laboratory values consistent with bleeding abnormalities and the presence of clinical symptoms of bleeding.

methodsWe conducted a record-based retrospective analysis of 112 children and adolescents referred to the Department of Hematology/Oncology at Children's Hospital of New Orleans for abnormal coagulation profiles and/or history of mucocutaneous bleeding. Participants were followed up until PTT values normalized.

resultsIn our study population with suspected bleeding disorder, the preliminary incidence of LA was 21%. We found that resolution of LA correlated with correction of PTT in 90% of patients.

conclusionTo minimize extensive and expensive blood workup, we recommend that screening for LA be included in the evaluation of children with prolonged PTT, even if they have a negative history of bleeding problems.

Indexed as

Antibodies–anticardiolipinlupus coagulation inhibitorlupus erythematosus–systemicpediatrics

Identifiers

PMID27303229

PMCPMC4896663

OpenAlexW2395167647

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.