ArticleProceedings of the National Academy of Sciences of the United States of America2016
Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes.Molecular microbiology · 2026Article
- A pleckstrin homology domain protein is involved in crystalloid formation inFrontiers in cellular and infection microbiology · 2026Article
- Palmitoylation in cancer: decoding its roles in signal transduction, tumor immunity, and emerging therapeutic opportunities.Frontiers in immunology · 2025Review
- Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle.International journal of molecular sciences · 2024Review
- Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella.Parasitology research · 2024Article
- The Multiple Roles of LCCL Domain-Containing Proteins for Malaria Parasite Transmission.Microorganisms · 2024Review
- Coordinated regulation of gene expression ineLife · 2024Article
- Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector.Cell host & microbe · 2023Article
- Article
- Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages.Molecular and biochemical parasitology · 2021Article
- Gliding motility protein LIMP promotes optimal mosquito midgut traversal and infection by Plasmodium berghei.Molecular and biochemical parasitology · 2021Article
- Plasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis.Journal of proteomics · 2020Article
- A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium.The EMBO journal · 2020Article
- NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission.EMBO reports · 2020Article
- Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes.Malaria journal · 2018Article
- The Plasmodium LAP complex affects crystalloid biogenesis and oocyst cell division.International journal for parasitology · 2018Article
- A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing.Molecular and biochemical parasitology · 2018Article
- Article
- Dynamic protein S-palmitoylation mediates parasite life cycle progression and diverse mechanisms of virulence.Critical reviews in biochemistry and molecular biology · 2017Review
- Palmitoylation of Plasmodium alveolins promotes cytoskeletal function.Molecular and biochemical parasitology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid-a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony-is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.
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