ArticleThe British journal of radiology2016
Diffusion tensor imaging of breast lesions: evaluation of apparent diffusion coefficient and fractional anisotropy and tissue cellularity.
Article in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Performance of Diffusion Tensor Imaging for Characterizing Breast Tumors: A Comprehensive Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Modification of RECIST 1.1 criteria for assessing response in breast tumours treated with radiation therapy using multiparametric breast MRI: Radiology and oncology perspective.Breast (Edinburgh, Scotland) · 2026Article
- Article
- Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma.Pediatric radiology · 2025Article
- Update on DWI for Breast Cancer Diagnosis and Treatment Monitoring.AJR. American journal of roentgenology · 2024Review
- Quantitative Diffusion-Weighted MRI of Neuroblastoma.Cancers · 2023Article
- Clinical utility of abbreviated breast MRI based on diffusion tensor imaging in patients underwent breast conservative therapy.La Radiologia medica · 2023Article
- Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding.BMC medical imaging · 2022Article
- Diffusion tensor imaging and diffusion-weighted imaging on axillary lymph node status in breast cancer patients.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology.Nature methods · 2022Article
- Article
- Denoising and Multiple Tissue Compartment Visualization of Multi-b-Valued Breast Diffusion MRI.Journal of magnetic resonance imaging : JMRI · 2021Article
- Diagnostic Value of Combined Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Diffusion Tensor Imaging in Predicting Parametrial Infiltration in Cervical Cancer.Contrast media & molecular imaging · 2021Article
- Detection of Glioblastoma Subclinical Recurrence Using Serial Diffusion Tensor Imaging.Cancers · 2020Article
- Diffusion-weighted MRI for Unenhanced Breast Cancer Screening.Radiology · 2019Review
- Diffusion tensor imaging for characterizing tumor microstructure and improving diagnostic performance on breast MRI: a prospective observational study.Breast cancer research : BCR · 2019Observational
- q-Space Imaging Yields a Higher Effect Gradient to Assess Cellularity than Conventional Diffusion-weighted Imaging Methods at 3.0 T: A Pilot Study with Freshly Excised Whole-Breast Tumors.Radiology. Imaging cancer · 2019Article
- Diagnostic value of diffusion-weighted imaging-derived apparent diffusion coefficient and its association with histological prognostic factors in breast cancer.Oncology letters · 2019Article
- DW-MRI of the breast: a pictorial review.Insights into imaging · 2019Article
- Diffusion MRI of cancer: From low to high b-values.Journal of magnetic resonance imaging : JMRI · 2019Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) measured by diffusion tensor imaging (DTI), tissue cellularity and their relationship in breast malignant/benign lesions.
methods88 patients with 88 breast lesions who underwent DTI and dynamic contrast-enhanced MR scanning between November 2013 and December 2014 were retrospectively analyzed. The diagnosis was confirmed pathologically. ADC and FA values as well as histopathological cellularity of different pathological types of lesions were analyzed and compared statistically. The Pearson's correlation between cellularity and ADC and FA was calculated.
resultsThere were 59 cases of breast cancer and 29 cases of benign lesions included in the study. ADC values of breast cancers were statistically lower than that of benign lesions (p < 0.001). FA and cellularity were higher in cancers than in benign lesions with statistical significance (p < 0.05 and p < 0.001, respectively). The mean FA values in the patients with invasive ductal carcinoma (IDC) were higher than that in the patients with ductal carcinoma in situ (DCIS) without statistical difference (p > 0.05). The ADC and the cellularity in the IDC of grade III were statistically lower (p < 0.05) and higher (p < 0.05) than that in the DCIS and IDC of grade I-II, respectively. ADC was negatively correlated to cellularity (r = -0.8319, p < 0.001) and FA was positively correlated to cellularity (r = 0.4231, p < 0.001).
conclusionADC and FA values were statistically different between benign and malignant breast lesions and were significantly correlated to tissue cellularity. ADC and FA may help to discriminate malignant from benign breast lesions and to predict cellularity. ADC is helpful in the prediction of the grade of breast cancer. ADVANCES IN KNOWLEDGE: ADC and FA values were statistically different between benign and malignant breast lesions and were significantly correlated to tissue cellularity.
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