ArticleBritish journal of clinical pharmacology2016
How does prescribing for antihypertensive products stack up against guideline recommendations? An Australian population-based study (2006-2014).
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Persistence and Adherence to Cardiovascular Medicines in Australia.Journal of the American Heart Association · 2023Article
- Blood pressure-lowering medication prescribing, its adherence to guidelines and relationship with blood pressure control at a family medicine department.Health science reports · 2023Article
- Incidence and risk factors of hypertension therapy in Australian cancer patients treated with vascular signalling pathway inhibitors.Discover oncology · 2022Article
- Antihypertensive medication use and blood pressure control among treated older adults.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study.PLoS medicine · 2018Article
- Prior experience with cardiovascular medicines predicted longer persistence in people initiated to combinations of antihypertensive and lipid-lowering therapies: findings from two Australian cohorts.Patient preference and adherence · 2018Article
- How does prescribing for antihypertensive products stack up against guideline recommendations? An Australian population-based study (2006-2014).British journal of clinical pharmacology · 2016Article
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Authors and funding
3 authors.
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Abstract
aimsWe describe choice of first-line antihypertensive drug therapy and uptake of fixed-dose combinations (FDCs) in Australia, and investigate the impact of initiation on FDCs and other non-recommended first-line therapies on treatment discontinuation.
methodThis was a population-based retrospective cohort study using a random 10% sample of persons dispensed an Australian Pharmaceutical Benefits Scheme listed medicine from 1 July 2005 to 30 June 2014. The primary outcomes were adherence to Australian recommendations at initiation of antihypertensive therapy, discontinuation of initial therapy and discontinuation of any therapy in the first year after initiation.
resultsIn our sample of 55 937 persons initiating therapy, 42.0% did so outside Australian recommendations, including not initiating on recommended monotherapy (26.3%) and not initiating on the lowest recommended dose (30.6%). Only 1.7% of individuals who were dispensed an FDC established therapy on the free combination regimen (as recommended) prior to switching. After adjusting for covariates, persons initiating on non-recommended monotherapy (OR = 2.64, 95% CI 2.47-2.83) or FDCs of two or more antihypertensives (OR = 1.42, 95% CI 1.30-1.55), were more likely to discontinue all antihypertensive drug treatment in the first year compared to persons initiating on recommended monotherapy.
conclusionMore than half of antihypertensive initiators conformed to Australian guidelines. Initiation on FDCs and other non-recommended treatments was associated with lower persistence on antihypertensive therapy in the first year. Long-term effectiveness and outcomes may be enhanced by initiating with low dose monotherapy.
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