Evidence map›Paper›PMID 27302328›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2017

Assessing Fever Frequency After Pediatric Live Attenuated Versus Inactivated Influenza Vaccination.

Melissa S Stockwell, Karen R Broder, Paige Lewis, Kathleen Jakob, Shahed Iqbal, Nadira Fernandez, Devindra Sharma, Angela Barrett, Philip LaRussa

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Influenza vaccines: Evaluation of the safety profile.Human vaccines & immunotherapeutics · 2018
    Review
  4. Observational
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Melissa S StockwellDepartment of Pediatrics.
Karen R BroderImmunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.
Paige LewisImmunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.
Kathleen JakobDepartment of Pediatrics.
Shahed IqbalImmunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nadira FernandezDepartment of Pediatrics.
Devindra SharmaImmunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.
Angela BarrettDepartment of Pediatrics.
Philip LaRussaDepartment of Pediatrics.
Pediatrics and Genetics · USCenters for Disease Control and Prevention · USNational Center for Immunization and Respiratory Diseases · USNew York Hospital Queens · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundSome studies have found a higher frequency of fever with trivalent live attenuated influenza vaccine (LAIV) than with inactivated influenza vaccine (IIV), but quadrivalent LAIV has not been assessed. Understanding fever is important for safety reviews and for parents and providers. In addition, there have been only a limited number of studies in which text messaging was used for vaccine adverse-event (AE) surveillance.

methodsWe conducted a prospective observational study in 3 community clinics in New York City to assess post-influenza vaccination fever in 24- to 59-month-olds during the 2013-2014 season. Enrolled families of children who received quadrivalent LAIV (LAIV4) or IIV (trivalent IIV3 or quadrivalent IIV4) replied to text messages that assessed their temperature on vaccination night and the next 10 nights (days 0 to 10); missing data were collected via telephone and a diary. We compared frequencies of fever (temperature ≥ 100.4°F) according to vaccine group on days 0 to 2 and 3 to 10 by using χ2 and multivariate log-binomial regression adjusted for age, previous influenza vaccination, and vaccine coadministration. We also assessed outcomes using all sources versus only text messages.

resultsMost (84.1% [n = 540]) eligible parents enrolled. Fever frequencies on days 0 to 2 did not differ between LAIV4 and any IIV (3.8% vs 5.7%, respectively; adjusted relative risk [aRR] [95% confidence interval], 0.60 [0.25-1.46]), between LAIV4 and IIV4 (4.2% vs 7.1%, respectively; aRR, 0.58 [0.19-1.72]), or between IIV4 and IIV3 (7.1% vs 6.0%, respectively; aRR, 1.02 [0.30-3.46]). The findings were similar when all data sources versus text-message data alone were used. There were no significant differences on days 3 to 10.

conclusionsPostvaccination fever frequencies were low overall and did not differ according to influenza vaccine type during the 2013-2014 influenza season. The similarity of results when data were limited to text messages lends support to its use for surveillance of vaccine adverse events.

Indexed as

Body TemperatureChild, PreschoolCommunity Health ServicesFemaleFeverHumansInfluenza, HumanInfluenza VaccinesMaleNew York CityPilot ProjectsProspective StudiesReaction TimeText MessagingTime FactorsVaccinationInfluenza VaccinesVaccines, AttenuatedVaccines, Inactivatedfeverinfluenzalive attenuatedtext messagevaccinationvaccine safety

Identifiers

PMID27302328
PMCPMC6675416
OpenAlexW2420093364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.