ArticleThe Journal of infectious diseases2016
Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 33 citations in OpenAlex.
- Respiratory pathogen epidemiology in the post-pandemic era: a multicenter retrospective study from Saudi Arabia.BMC infectious diseases · 2026Article
- Operational zoonotic containment of Middle East respiratory syndrome coronavirus in Saudi Arabia: An implementation-oriented One Health genomic framework.Veterinary world · 2026Review
- Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023-2024.Emerging infectious diseases · 2025Article
- Genomic Diversity and Recombination Analysis of the Spike Protein Gene from Selected Human Coronaviruses.Biology · 2024Article
- Isolation and genetic characterization of MERS-CoV from dromedary camels in the United Arab Emirates.Frontiers in veterinary science · 2023Article
- The Impact of Maternal Prenatal Stress Related to the COVID-19 Pandemic during the First 1000 Days: A Historical Perspective.International journal of environmental research and public health · 2022Review
- Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.Nature communications · 2021Article
- Phylogenetic Analysis of MERS-CoV in a Camel Abattoir, Saudi Arabia, 2016-2018.Emerging infectious diseases · 2020Article
- Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV).Journal of infection and public health · 2020Article
- Article
- Genetic diversity of MERS-CoV spike protein gene in Saudi Arabia.Journal of infection and public health · 2020Article
- A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences.Scientific data · 2019Article
- Epitope-based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study.Journal of translational medicine · 2019Article
- Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2017-2018.Emerging infectious diseases · 2019Article
- Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015.The Journal of general virology · 2019Article
- Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.Cell reports · 2019Article
- A Review of Zoonotic Pathogens of Dromedary Camels.EcoHealth · 2019Review
- Article
- Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia.Emerging infectious diseases · 2019Article
- Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017.Infection control and hospital epidemiology · 2019Article
Corrections and comments
- Erratum issuedErratum.2019
Authors and funding
28 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.
methodsWe assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January-30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.
resultsDuring the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015. DISCUSSIONS: Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.