ArticleScientific reports2016
Effects of acute spinalization on neurons of postural networks.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Central mechanisms of muscle tone regulation: implications for pain and performance.Frontiers in neuroscience · 2024Article
- Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord.The Journal of physiology · 2023Article
- Changes in Activity of Spinal Postural Networks at Different Time Points After Spinalization.Frontiers in cellular neuroscience · 2019Article
- Effect of acute lateral hemisection of the spinal cord on spinal neurons of postural networks.Neuroscience · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons, and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization, and represent a starting point for the development of spasticity.
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