ArticleScientific reports2016
Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Infection control and anti-apoptotic effect of Lactobacillus paracasei derivatives on fibroblasts through modulation of BCL2 transcription.Archives of microbiology · 2026Article
- Polyelectrolyte Complex Coacervate Adhesive for Wearable Medical Devices.Macromolecular rapid communications · 2025Article
- Acidic environment could modulate the interferon-γ expression: Implication on modulation of cancer and immune cells' interactions.Asian biomedicine : research, reviews and news · 2023Article
- pH-Responsive nanofiber buttresses as local drug delivery devices.Biomaterials science · 2023Article
- Cancer cells same as zombies reprogram normal cells via the secreted microenvironment.PloS one · 2023Article
- Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors.iScience · 2022Article
- The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma.Advanced therapeutics · 2020Article
- Smart Responsive Nanoformulation for Targeted Delivery of Active Compounds From Traditional Chinese Medicine.Frontiers in chemistry · 2020Review
- The Upregulation of OCT4 in Acidic Extracellular pH is Associated with Gemcitabine Resistance in Cholangiocarcinoma Cell Lines.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a SequelaInternational journal of molecular sciences · 2019Review
- Article
- Potential Therapies for Infectious Diseases Based on Targeting Immune Evasion Mechanisms That Pathogens Have in Common With Cancer Cells.Frontiers in cellular and infection microbiology · 2019Article
- Morphology-dependent pH-responsive release of hydrophilic payloads using biodegradable nanocarriers.RSC advances · 2018Article
- Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins.Theranostics · 2018Article
- Curcumin encapsulated zeolitic imidazolate frameworks as stimuli responsive drug delivery system and their interaction with biomimetic environment.Scientific reports · 2017Article
- Cancer Chemotherapy Specific to Acidic Nests.Cancers · 2017Review
- ASIC1a mediates the drug resistance of human hepatocellular carcinoma via the CaLaboratory investigation; a journal of technical methods and pathology · 2017Article
- Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Octamer-binding transcription factor 4 (OCT-4) is an important marker of cellular de-differentiation that can be induced by environmental stressors, such as acidity. Here we demonstrate that chronic acidic stress in solid tumors induced OCT-4 expression in fibroblasts and other stromal cells in four tumor models. The results have implications for how tumors utilize pH modulation to recruit associated stromal cells, induce partial reprogramming of tumor-associated stromal cells, and respond to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.