ArticleEnvironmental monitoring and assessment2016
Autism spectrum disorder prevalence and associations with air concentrations of lead, mercury, and arsenic.
Article in Environmental monitoring and assessment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Evidence of susceptibility to autism risks associated with early life ambient air pollution: A systematic review.Environmental research · 2022Pooled it
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- Nickase NmCas9 unsilences paternal Ube3a in a mouse model of Angelman syndrome without causing AAV vector integration.Scientific reports · 2026Article
- Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome.Gene therapy · 2026Article
- Prenatal ozone exposure and risk of intellectual disability.Journal of exposure science & environmental epidemiology · 2026Article
- Essential and non-essential metals in children's intellectual functioning: A multi-media biomarker approach from a Mexico City birth cohort.Environmental research · 2025Article
- Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Article
- Expanding Research on Contextual Factors in Autism Research: What Took Us So Long?Autism research : official journal of the International Society for Autism Research · 2025Article
- Observational methods for human studies of transgenerational effects.Epigenetics · 2024Article
- AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort.Environmental health perspectives · 2024Article
- An ecological study shows increased prevalence of autism spectrum disorder in children living in a heavily polluted area.Scientific reports · 2024Article
- Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children.Current pediatric reviews · 2024Review
- Early-Life Lead Exposure: Risks and Neurotoxic Consequences.Current medicinal chemistry · 2024Review
- Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.Biomolecules · 2023Review
- Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature.Environmental health perspectives · 2023Article
- Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.Exposure and health · 2023Article
- Hair Trace Elements and Mineral Content in Moroccan Children with Autism Spectrum Disorder: a Case-Control Study.Biological trace element research · 2023Article
- Prenatal socioenvironmental exposures and autism spectrum disorder: A web of confusion.Child development perspectives · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead, mercury, and arsenic are neurotoxicants with known effects on neurodevelopment. Autism spectrum disorder (ASD) is a neurodevelopmental disorder apparent by early childhood. Using data on 4486 children with ASD residing in 2489 census tracts in five sites of the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network, we used multi-level negative binomial models to investigate if ambient lead, mercury, and arsenic concentrations, as measured by the US Environmental Protection Agency National-Scale Air Toxics Assessment (EPA-NATA), were associated with ASD prevalence. In unadjusted analyses, ambient metal concentrations were negatively associated with ASD prevalence. After adjusting for confounding factors, tracts with air concentrations of lead in the highest quartile had significantly higher ASD prevalence than tracts with lead concentrations in the lowest quartile (prevalence ratio (PR) = 1.36; 95 '% CI: 1.18, 1.57). In addition, tracts with mercury concentrations above the 75th percentile (>1.7 ng/m(3)) and arsenic concentrations below the 75th percentile (≤0.13 ng/m(3)) had a significantly higher ASD prevalence (adjusted RR = 1.20; 95 % CI: 1.03, 1.40) compared to tracts with arsenic, lead, and mercury concentrations below the 75th percentile. Our results suggest a possible association between ambient lead concentrations and ASD prevalence and demonstrate that exposure to multiple metals may have synergistic effects on ASD prevalence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.