ArticleStroke2016
Prophylactic Antiepileptics and Seizure Incidence Following Subarachnoid Hemorrhage: A Propensity Score-Matched Analysis.
Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Guidelines for Seizure Prophylaxis in Patients with Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society.Neurocritical care · 2026Guideline
- Duration and choices of prophylactic anticonvulsants in subarachnoid hemorrhage: a systematic review and meta-analysis.Neurosurgical review · 2021Pooled it
- Seizure incidence of angiogram-negative subarachnoid hemorrhage: An updated meta-analysis.Journal of the Chinese Medical Association : JCMA · 2020Pooled it
- A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2018Trial
- Incidence of Early and In-hospital Late Seizures Following Aneurysmal Subarachnoid Hemorrhage in Patients Treated with Clazosentan: A Multicenter Retrospective Cohort Study.Neurologia medico-chirurgica · 2026Article
- Influence of epilepsy and antiepileptic drug intake in patients suffering from aneurysmal subarachnoid hemorrhage on outcome.Brain & spine · 2026Article
- Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section.Neurological research and practice · 2025Article
- Emerging Treatments for Subarachnoid Hemorrhage.CNS & neurological disorders drug targets · 2024Review
- Emergency Medical Management of Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2023Article
- Acute Multidisciplinary Management of Aneurysmal Subarachnoid Hemorrhage (aSAH).Balkan medical journal · 2023Review
- Emerging Role of Microglia-Mediated Neuroinflammation in Epilepsy after Subarachnoid Hemorrhage.Molecular neurobiology · 2021Review
- Discontinuation of preventive antiepileptic drugs in patients with intracerebral hemorrhage.BMC neurology · 2021Article
- Incidence of Electrographic Seizures in Patients With COVID-19.Frontiers in neurology · 2021Article
- A Questionnaire Survey of Management of Patients with Aneurysmal Subarachnoid Haemorrhage in Poland.International journal of environmental research and public health · 2020Article
- Comparison of machine learning models for seizure prediction in hospitalized patients.Annals of clinical and translational neurology · 2019Article
- Prophylactic Seizure Medication and Health-Related Quality of Life After Intracerebral Hemorrhage.Critical care medicine · 2018Article
- Antiepileptic drugs in critically ill patients.Critical care (London, England) · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe utility of prophylactic antiepileptic drug (AED) administration after spontaneous subarachnoid hemorrhage remains controversial. AEDs have not clearly been associated with a reduction in seizure incidence and have been associated with both neurological worsening and delayed functional recovery in this setting.
methodsWe retrospectively analyzed a prospectively collected database of subarachnoid hemorrhage patients admitted to our institution between 2005 and 2010. Between 2005 and 2007, all patients received prophylactic AEDs upon admission. After 2007, no patients received prophylactic AEDs or had AEDs immediately discontinued if initiated at an outside hospital. A propensity score-matched analysis was then performed to compare the development of clinical and electrographic seizures in these 2 populations.
resultsThree hundred and fifty three patients with spontaneous subarachnoid hemorrhage were analyzed, 43% of whom were treated with prophylactic AEDs upon admission. Overall, 10% of patients suffered clinical and electrographic seizures, most frequently occurring within 24 hours of ictus (47%). The incidence of seizures did not vary significantly based on the use of prophylactic AEDs (11 versus 8%; P=0.33). Propensity score-matched analyses suggest that patients receiving prophylactic AEDs had a similar likelihood of suffering seizures as those who did not (P=0.49).
conclusionsPropensity score-matched analysis suggests that prophylactic AEDs do not significantly reduce the risk of seizure occurrence in patients with spontaneous subarachnoid hemorrhage.
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Registered trials
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