ArticleAnnals of surgical oncology2016
Using the Comprehensive Complication Index to Assess the Impact of Neoadjuvant Chemoradiotherapy on Complication Severity After Esophagectomy for Cancer.
Article in Annals of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Fluorescence Lymphography Using Indocyanine Green During Esophagectomy for Cancer to Prevent Chyle Leakage: A Propensity Score Matched Analysis.Annals of surgical oncology · 2026Observational
- Inadequate preoperative smoking cessation fails to improve outcomes after esophagectomy.Journal of cardiothoracic surgery · 2026Article
- Review
- The crossroads of inflammation and nutrition: predicting neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma patients.Frontiers in immunology · 2025Article
- Debating the Optimal Preoperative Approach: NACRT vs NACT in Locally Advanced Oesophageal Cancer.Indian journal of surgical oncology · 2024Article
- Efficiency and Complications of Esophageal Stenting in the Management of Postoperative Fistulas.Journal of clinical medicine · 2024Article
- Safe Transition from Open to Total Minimally Invasive Esophagectomy for Cancer Utilizing Process Management Methodology.Journal of clinical medicine · 2024Article
- National clinical and financial outcomes associated with acute kidney injury following esophagectomy for cancer.PloS one · 2024Article
- Risk Factors for a High Comprehensive Complication Index after Splenectomy Plus Pericardial Devascularization for Portal Hypertension.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Clinical implications of chyle leakage following esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Article
- Article
- Propensity-matched analysis of the efficacy of olanexidine gluconate versus chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy.BMC surgery · 2022Article
- Article
- Anastomotic leakage after esophagectomy for esophageal cancer: definitions, diagnostics, and treatment.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Review
- Impact of Radiation Dose on Postoperative Complications in Esophageal and Gastroesophageal Junction Cancers.Frontiers in oncology · 2021Article
- Multidisciplinary treatment of esophageal cancer: The role of active surveillance after neoadjuvant chemoradiation.Annals of gastroenterological surgery · 2020Review
- Minimally invasive mesoesophageal resection.Journal of thoracic disease · 2019Review
- Postoperative survival analysis and prognostic nomogram model for patients with portal hypertension.World journal of gastroenterology · 2018Article
- Long-term results of neoadjuvant chemoradiotherapy using cisplatin and 5-fluorouracil followed by esophagectomy for resectable, locally advanced esophageal squamous cell carcinoma.Journal of radiation research · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoadjuvant chemoradiotherapy (nCRT) followed by surgery for patients with esophageal or junctional cancer has become a standard of care. The comprehensive complication index (CCI) has recently been developed and accounts for all postoperative complications. Hence, CCI better reflects the burden of all combined postoperative complications in surgical patients than the Clavien-Dindo score alone, which incorporates only the most severe complication. This study was designed to evaluate the severity of complications in patients treated with nCRT followed by esophagectomy versus in patients who underwent esophagectomy alone using the comprehensive complication index. STUDY-
designAll patients included in the CROSS trial-a randomized, clinical trial on the value of nCRT followed by esophagectomy-were included. Complications were assessed and graded using the Clavien-Dindo classification. CCI was derived from these scores, using the CCI calculator available online ( www.assessurgery.com ). CCI of patients who underwent nCRT followed by surgery was compared with the CCI of patients who underwent surgery alone.
resultsIn both groups 161 patients were included. The median (and interquartile range) CCI of patients with nCRT and surgery was 26.22 (17.28-42.43) versus 25.74 (8.66-43.01) in patients who underwent surgery alone (p = 0.58). There also was no difference in CCI between subgroups of patients with anastomotic leakage, pulmonary complications, cardiac complications, thromboembolic events, chyle leakage, and wound infections.
conclusionsNeoadjuvant chemoradiotherapy according to CROSS did not have a negative impact on postoperative complication severity expressed by CCI compared with patients who underwent surgery alone for potentially curable esophageal or junctional cancer.
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