ArticleScientific reports2016
Optoacoustic effect is responsible for laser-induced cochlear responses.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Optical induction of auditory perception via cochlear stimulation in Mongolian gerbils without genetic modification.iScience · 2026Article
- Intensity modulation of frequency-specific optoacoustic stimulation at the peripheral hearing level.Zeitschrift fur medizinische Physik · 2026Article
- Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Blue Light-Induced, Dosed Protein Expression of Active BDNF in Human Cells Using the Optogenetic CRY2/CIB System.Biotechnology journal · 2024Article
- Acoustic stimulation of the human round window by laser-induced nonlinear optoacoustics.Scientific reports · 2024Article
- Review
- Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus.Scientific reports · 2023Article
- Is there an unmet medical need for improved hearing restoration?EMBO molecular medicine · 2022Review
- Article
- Channel Interaction During Infrared Light Stimulation in the Cochlea.Lasers in surgery and medicine · 2021Article
- Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film.Journal of biomedical optics · 2021Article
- Infrared neural stimulation at different wavelengths and pulse shapes.Progress in biophysics and molecular biology · 2021Article
- Near-infrared stimulation of the auditory nerve: A decade of progress toward an optical cochlear implant.Laryngoscope investigative otolaryngology · 2021Review
- Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system.Neurophotonics · 2021Article
- Cochlear implants and other inner ear prostheses: today and tomorrow.Current opinion in physiology · 2020Article
- Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents.Science translational medicine · 2020Article
- Optical stimulation of neural tissue.Healthcare technology letters · 2020Article
- Towards the optical cochlear implant: optogenetic approaches for hearing restoration.EMBO molecular medicine · 2020Review
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical stimulation of the cochlea with laser light has been suggested as an alternative to conventional treatment of sensorineural hearing loss with cochlear implants. The underlying mechanisms are controversially discussed: The stimulation can either be based on a direct excitation of neurons, or it is a result of an optoacoustic pressure wave acting on the basilar membrane. Animal studies comparing the intra-cochlear optical stimulation of hearing and deafened guinea pigs have indicated that the stimulation requires intact hair cells. Therefore, optoacoustic stimulation seems to be the underlying mechanism. The present study investigates optoacoustic characteristics using pulsed laser stimulation for in vivo experiments on hearing guinea pigs and pressure measurements in water. As a result, in vivo as well as pressure measurements showed corresponding signal shapes. The amplitude of the signal for both measurements depended on the absorption coefficient and on the maximum of the first time-derivative of laser pulse power (velocity of heat deposition). In conclusion, the pressure measurements directly demonstrated that laser light generates acoustic waves, with amplitudes suitable for stimulating the (partially) intact cochlea. These findings corroborate optoacoustic as the basic mechanism of optical intra-cochlear stimulation.
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