Evidence map›Paper›PMID 27301743›Full record

ArticleJournal of neuroinflammation2016

Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury.

Valeria Sasso, Elisa Bisicchia, Laura Latini, Veronica Ghiglieri, Fabrizio Cacace, Valeria Carola, Marco Molinari, Maria Teresa Viscomi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940609 (Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06940609 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)

TypeinterventionalSponsorUniversity of New MexicoRan2025 to 2029Enrolled60ConditionsLong COVID, Long COVID Syndrome, Long COVID-19 Syndrome, PASCArmsaccelerated intermittent theta burst stimulation
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valeria SassoSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Elisa BisicchiaSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Laura LatiniSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Veronica GhiglieriSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Fabrizio CacaceSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Valeria CarolaSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Marco MolinariSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Maria Teresa ViscomiSanta Lucia Foundation, I.R.C.C.S., Via del Fosso di Fiorano 64, 00143, Rome, Italy. mt.viscomi@hsantalucia.it.ORCID 0000-0002-9096-4967
Fondazione Santa Lucia · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAfter focal brain injuries occur, in addition to the effects that are attributable to the primary site of damage, the resulting functional impairments depend highly on changes that occur in regions that are remote but functionally connected to the site of injury. Such effects are associated with apoptotic and inflammatory cascades and are considered to be important predictors of outcome. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that is used to treat various central nervous system (CNS) pathologies and enhance functional recovery after brain damage.

objectiveThis study examined the efficacy of rTMS in mitigating remote degeneration and inflammation and in improving functional recovery in a model of focal brain damage.

methodsRats that were undergoing hemicerebellectomy (HCb) were treated with an rTMS protocol for 7 days, and neuronal death indices, glial activation, and functional recovery were assessed.

resultsrTMS significantly reduced neuronal death and glial activation in remote regions and improved functional recovery.

conclusionsOur finding opens up a completely new scenario for exploiting the potential of rTMS as an anti-apoptotic and anti-inflammatory treatment.

Indexed as

Transcranial Magnetic StimulationAnimalsApoptosisBrain InjuriesCalcium-Binding ProteinsCytochromes cDisease Models, AnimalGene Expression RegulationGlial Fibrillary Acidic ProteinInflammationMaleMicrofilament ProteinsNeurogliaPhosphopyruvate HydrataseRatsRats, WistarAif1 protein, ratCalcium-Binding ProteinsCytochromes cGlial Fibrillary Acidic ProteinMicrofilament ProteinsPhosphopyruvate HydrataseRNA, MessengerApoptosisGlial activationInflammationNeuroprotectionRemote degenerationTranscranial magnetic stimulation

Identifiers

PMID27301743
PMCPMC4908713
OpenAlexW2424408772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.