ArticleExperimental animals2016
Effects of inducing exercise on growing mice by means of three-dimensional structure in rearing environment.
Article in Experimental animals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Welfare Assessment of Female BALB/c Mice Housed with Different Environmental Enrichment Materials.Animals : an open access journal from MDPI · 2026Article
- Biological characteristics and immune responses of NK Cells in commonly used experimental mouse models.Frontiers in immunology · 2024Review
- Aggression in Group-Housed Male Mice: A Systematic Review.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reared ICR mice during a growth period (3 to 10 weeks of age) and examined the effect of exercise induction, by enriching the rearing environment with obstacles such as ladders, compared to the standard environment. Environmental enrichment significantly increased the amount of exercise in both sexes (P<0.01). Enriched exercise mice had higher body weight than control mice at 6 to 9 weeks of age in males and 8 weeks of age in females (P<0.05). The sexual maturation of female enriched exercise mice was significantly advanced compared to the control (P<0.001). Enriched exercise mice showed decreased anxiety-like behavior in the open field test and lower plasma corticosterone levels in both sexes compared to the control, and differences were statistically significant in males (P<0.05). In both sexes, enriched exercise appeared to increase natural killer cells in blood compared to the control, but no statistical differences was detected. In conclusion, we confirmed that daily low-stress exercise could be induced using a three-dimensional rearing environment in growing mice. In addition, we suggest that exercise has beneficial effects on physical growth, sexual maturation and anxiety-like behavior. Furthermore, environmental enrichment might be more effective in male than female in group-housed mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.