ArticleExperimental animals2016
Different sensitivity to the suppressive effects of isoflurane anesthesia on cardiorespiratory function in SHR/Izm, WKY/Izm, and Crl:CD (SD) rats.
Article in Experimental animals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- The cardioprotective effects of acteoside in myocardial ischemia reperfusion injury and the underlying mechanism.BMC cardiovascular disorders · 2025Article
- Optimization of inhaled anesthesia for Octodon degus using electroencephalography.Experimental animals · 2025Article
- Respiratory rate as a X-ray-based biomarker for the longitudinal assessment of lung function and pathology.Frontiers in medicine · 2025Article
- Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.BMC anesthesiology · 2023Article
- Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease.American journal of physiology. Heart and circulatory physiology · 2021Article
- Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane.PloS one · 2021Article
- Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice.Lab animal · 2021Article
- Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids.The Journal of physiology · 2020Article
- Measuring Arterial Stiffness in Animal Experimental Studies.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Real-time measurement of small molecules directly in awake, ambulatory animals.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isoflurane is a widely used anesthetic, but its effects with increase in inspired concentration on cardiovascular function have not yet been clarified in rodents. Additionally, there are only a few studies comparing isoflurane-induced cardiorespiratory effects between rat strains. Thus, we investigated the differences in cardiorespiratory responsiveness to increasing concentration of inspired isoflurane in SHR/Izm, WKY/Izm and Crl:CD (SD) rats, by increasing the setting values of vaporizer's dial indicator. The rats were anesthetized with 1.5% isoflurane, and electrocardiograms, blood pressure, and respiratory rate were recorded simultaneously. Thereafter, the inspired concentration was increased stepwise to 2%, 3%, 4%, and 5%, and cardiorespiratory parameters were obtained at each concentration. Under anesthesia at more than 4%, although prolongation of the RR and PR intervals was observed in all strains, shortening of the QT
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