ArticleScientific reports2016
Transformation of Breast Reconstruction via Additive Biomanufacturing.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Breast Reconstruction with a Tissue Engineering and Regenerative Medicine Approach (Systematic Review).Annals of biomedical engineering · 2020Pooled it
- Cell-free biomimetic polyurethane-based scaffold for breast reconstruction following non-malignant lesion resection. A first-in-human study.Breast cancer (Tokyo, Japan) · 2023Trial
- Adipose Tissue Engineering Biomaterials: Smart Scaffolds, Vascularization, and Clinical Frontiers.Biomolecules · 2026Review
- Investigating the foreign body response and regenerative mechanisms in medical-grade polycaprolactone scaffold guided breast reconstruction in a porcine model.Frontiers in bioengineering and biotechnology · 2026Article
- State of Research on Tissue Engineering with 3D Printing for Breast Reconstruction.Journal of clinical medicine · 2025Review
- Porous granular hydrogel scaffolds biofabricated from dual-crosslinked hydrogel microparticles for breast tissue engineering.Materials today. Bio · 2025Article
- Review
- Article
- Clinically Relevant and Precisely Printable Live Adipose Tissue-Based Bio-Ink for Volumetric Soft Tissue Reconstruction.Advanced healthcare materials · 2025Article
- Human breast tissue engineering in health and disease.EMBO molecular medicine · 2024Review
- Establishment of Early Blood Perfusion Promotes CXCL12 Expression and Recruits Monocytes/Macrophages in Damaged Adipose Tissue in Mice Model.Aesthetic plastic surgery · 2024Article
- Advanced Hydrogels in Breast Cancer Therapy.Gels (Basel, Switzerland) · 2024Review
- Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model.Bioengineering (Basel, Switzerland) · 2024Article
- Three-Dimensional Printing in Breast Reconstruction: Current and Promising Applications.Journal of clinical medicine · 2024Review
- Adipogenesis of bioabsorbable implants under irradiation in a rodent model.Regenerative therapy · 2024Article
- Evaluation of adipogenesis over time using a novel bioabsorbable implant without the addition of exogenous cells or growth factors.Regenerative therapy · 2024Article
- Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions.Annals of translational medicine · 2024Review
- Engineering 3D-Printed Bioresorbable Scaffold to Improve Non-Vascularized Fat Grafting: A Proof-of-Concept Study.Biomedicines · 2023Article
- Long term observation ofRegenerative therapy · 2023Article
- Development of new bioabsorbable implants with de novo adipogenesis.Regenerative therapy · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipose tissue engineering offers a promising alternative to current breast reconstruction options. However, the conventional approach of using a scaffold in combination with adipose-derived precursor cells poses several problems in terms of scalability and hence clinical feasibility. Following the body-as-a-bioreactor approach, this study proposes a unique concept of delayed fat injection into an additive biomanufactured and custom-made scaffold. Three study groups were evaluated: Empty scaffold, Scaffold containing 4 cm(3) lipoaspirate and Empty scaffold +2-week prevascularisation period. In group 3, of prevascularisation, 4 cm(3) of lipoaspirate was injected into scaffolds after 2 weeks. Using a well-characterised additive biomanufacturing technology platform, patient-specific scaffolds made of medical-grade-polycaprolactone were designed and fabricated. Scaffolds were implanted in subglandular pockets in immunocompetent minipigs (n = 4) for 24-weeks. Angiogenesis and adipose tissue regeneration were observed in all constructs. Histological evaluation showed that the prevascularisation + lipoaspirate group had the highest relative area of adipose tissue (47.32% ± 4.12) which was significantly higher than both lipoaspirate-only (39.67% ± 2.04) and empty control group (8.31% ± 8.94) and similar to native breast tissue (44.97% ± 14.12). This large preclinical animal study provides proof-of-principle that the clinically applicable prevascularisation and delayed fat-injection techniques can be used for regeneration of large volumes of adipose tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.