Evidence map›Paper›PMID 27301371›Full record

ArticleAesthetic surgery journal2016

Efficacy and Safety of a Hyaluronic Acid Filler to Correct Aesthetically Detracting or Deficient Features of the Asian Nose: A Prospective, Open-Label, Long-Term Study.

Steven Liew, Terrence Scamp, Mauricio de Maio, Michael Halstead, Nicole Johnston, Michael Silberberg, John D Rogers

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aesthetic surgery journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01846039 (A Prospective, Open-label Study of the Safety and Efficacy of JUVÉDERM VOLUMA® to Enhance the Aesthetic Appearance of the Asian Nose), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01846039 nacompletednot on this map

A Prospective, Open-label Study of the Safety and Efficacy of JUVÉDERM VOLUMA® to Enhance the Aesthetic Appearance of the Asian Nose

TypeinterventionalSponsorAllerganRan2013 to 2014Enrolled29ConditionsAsian Nose EnhancementArmsCrosslinked hyaluronic acid gel
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  19. Nasal Dorsum Augmentation with Botulinum Toxin A: A Pilot Study.The Journal of clinical and aesthetic dermatology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Steven LiewDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Terrence ScampDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Mauricio de MaioDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Michael HalsteadDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Nicole JohnstonDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Michael SilberbergDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
John D RogersDr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Allergan (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia.

objectivesTo evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose.

methodsTwenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvéderm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months.

resultsA clinically meaningful correction (≥1 grade improvement on the Assessment of Aesthetic Improvement Scale) was achieved in 27 (93.1%) patients at the first follow-up visit. This was maintained in 28 (96.6%) patients at the final visit, based on the independent assessments of a central non-injecting physician and the patients. At this final visit, 23 (79.3%) patients were satisfied or very satisfied with the study filler and 25 (86.2%) would recommend it to others. In this small series of patients, there were no serious adverse events (AEs), with all treatment-related AEs being mild to moderate, transient injection site reactions, unrelated to the study filler.

conclusionsUsing specific eligibility criteria, individualized treatment goals, and a standardized injection procedure, the study filler corrected aesthetically detracting or deficient features of the Asian nose, with the therapeutic effects lasting for over 12 months, consistent with a high degree of patient satisfaction. This study supports the safety and efficacy of this HA filler for specific nose augmentation procedures in selected Asian patients. LEVEL OF EVIDENCE 3: Therapeutic.

Indexed as

Cosmetic TechniquesNoseAdultAsiaDermatologic AgentsEstheticsFemaleFollow-Up StudiesHumansHyaluronic AcidMaleMiddle AgedPatient SatisfactionProspective StudiesTreatment OutcomeYoung AdultDermatologic AgentsHyaluronic AcidJuvéderm

Identifiers

PMID27301371
PMCPMC4911905
OpenAlexW2426033550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.