ArticleScientific reports2016
In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Research and application advances in real-time single-cell functional analysis.Discover nano · 2026Review
- Biomaterials for neuroengineering: applications and challenges.Regenerative biomaterials · 2025Review
- Superlative and Selective Sensing of Serotonin in Undiluted Human Serum Using Novel Polystyrene Sulfonate Conductive Polymer.ACS omega · 2024Article
- Molecularly imprinted miniature electrochemical biosensor for SARS-CoV-2 spike protein based on Au nanoparticles and reduced graphene oxide modified acupuncture needle.Bioelectrochemistry (Amsterdam, Netherlands) · 2023Article
- Studies of Monoamine Neurotransmitters at Nanomolar Levels Using Carbon Material Electrodes: A Review.Materials (Basel, Switzerland) · 2022Review
- Preventing the induction of acid saline-induced fibromyalgia pain in mice by electroacupuncture or APETx2 injection.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2020Article
- Enzymatic Platforms for Sensitive Neurotransmitter Detection.Sensors (Basel, Switzerland) · 2020Article
- Bifunctional hexagonal Ni/NiO nanostructures: influence of the core-shell phase on magnetism, electrochemical sensing of serotonin, and catalytic reduction of 4-nitrophenol.Nanoscale advances · 2019Article
- Nanomaterial based electrochemical sensing of the biomarker serotonin: a comprehensive review.Mikrochimica acta · 2019Review
- Understanding Acupoint Sensitization: A Narrative Review on Phenomena, Potential Mechanism, and Clinical Application.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Traditional Acupuncture Meets Modern Nanotechnology: Opportunities and Perspectives.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- A sensitive acupuncture needle microsensor for real-time monitoring of nitric oxide in acupoints of rats.Scientific reports · 2017Article
- Distribution of Mast Cells and Locations, Depths, and Sizes of the Putative Acupoints CV 8 and KI 16.Evidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture treatment is amazing but controversial. Up to now, the mechanism of treating diseases by acupuncture and moxibustion is still unclear, especially the occurrence of the molecular events in local acupoints. Herein, we report an extremely stable microsensor by modifying carbon nanotube (CNT) to the tip surface of acupuncture needle and applying this CNT-modified acupuncture needle for real time monitoring of serotonin (5-HT) in vivo. To stabilize CNT modification on the needle tip surface, poly(3,4-ethylenedioxythiophene)(PEDOT) was employed as glue water to stick CNT on the needle. The detection limit of the CNT-modified needle was found to be approximately 50 nM and 78 nM in the PBS and the cell medium, respectively. In addition, the needle showed good selectivity to some inflammatory mediators and some electroactive molecules. For the first time, the CNT-modified needle could be directly probed into rat body for real time monitoring of 5-HT in vivo, showing a great potential for better understanding the mechanism of acupuncture treatment.
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Registered trials
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