Evidence map›Paper›PMID 27300741›Full record

ArticlePediatric radiology2016

Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study.

Hirofumi Tomita, Kiyoshi Ohkuma, Yohei Masugi, Naoki Hosoe, Ken Hoshino, Yasushi Fuchimoto, Akihiro Fujino, Takahiro Shimizu, Mototoshi Kato, Takumi Fujimura and 8 more

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In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Hirofumi TomitaDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan. htomita@a3.keio.jp.
Kiyoshi OhkumaDepartment of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Yohei MasugiDepartment of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Naoki HosoeCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Ken HoshinoDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Yasushi FuchimotoDivision of Surgery, Department of Surgical Subspecialties, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, 157-8535, Japan.
Akihiro FujinoDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Takahiro ShimizuDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Mototoshi KatoDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Takumi FujimuraDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Hideo IshihamaDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Nobuhiro TakahashiDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Yutaka TanamiDepartment of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Hirotoshi EbinumaDepartment of Internal Medicine, Saitama City Hospital, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Hidetsugu SaitoDepartment of Internal Medicine, Saitama City Hospital, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Michiie SakamotoDepartment of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Miwako NakanoDepartment of Pediatric Surgery, Saitama City Hospital, 2460 Mimuro, Midori-ku,, Saitama-shi, 336-8522, Japan.
Tatsuo KurodaDepartment of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku,, Tokyo, 160-8582, Japan.
Keio University Hospital · JPNational Center For Child Health and Development · JPSaitama Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices.

objectiveTo evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presence of esophageal varices in patients treated for biliary atresia. MATERIALS AND

methodsARFI imaging of the spleen and native liver was performed in 28 patients with biliary atresia. We studied the relation between ARFI imaging values and liver histology findings (n=22), upper gastrointestinal endoscopy findings (n=16) and several noninvasive test results. Diagnostic accuracy was assessed using receiver operating characteristic curve analyses.

resultsLiver stiffness measurements exhibited a significant difference among the different grades of liver fibrosis (P=0.009), and showed higher values in patients with high-risk esophageal varices than in the other patients (P=0.04). The areas under the receiver operating characteristic curves of liver stiffness measurements for liver fibrosis grades  ≥ F2, ≥F3 and = F4 were 0.83, 0.93 and 0.94, respectively. Patients with high-risk esophageal varices were preferentially diagnosed by the combined liver and spleen stiffness measurements (area under the curve, 0.92).

conclusionLiver and spleen stiffness measurements using ARFI imaging are potential noninvasive markers for liver fibrosis and esophageal varices in patients treated for biliary atresia.

Indexed as

Elasticity Imaging TechniquesAdolescentAdultBiliary AtresiaChildChild, PreschoolEsophageal and Gastric VaricesFemaleHumansInfantLiver CirrhosisMalePilot ProjectsSpleenAcoustic radiation force impulse imagingBiliary atresiaEsophageal varicesLiverLiver fibrosisLiver stiffnessSpleen stiffness

Identifiers

PMID27300741
OpenAlexW2432564266

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.