Evidence map›Paper›PMID 27300696›Full record

ArticleHIV clinical trials2016

CXCR4-using HIV variants in a cohort of Black men who have sex with men: HIV Prevention Trials Network 061.

Iris Chen, Wei Huang, Matthew B Connor, Arne Frantzell, Vanessa Cummings, Geetha G Beauchamp, Sam Griffith, Sheldon D Fields, Hyman M Scott, Steven Shoptaw and 8 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV clinical trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 1 country.

Iris Chena Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Wei Huangb Monogram Biosciences , South San Francisco , CA , USA.
Matthew B Connorc Vaccine and Infectious Disease Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Arne Frantzellb Monogram Biosciences , South San Francisco , CA , USA.
Vanessa Cummingsa Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Geetha G Beauchampc Vaccine and Infectious Disease Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Sam Griffithd Science Facilitation Department , FHI 360 , Durham , NC , USA.
Sheldon D Fieldse Mervyn M. Dymally School of Nursing , Charles R. Drew University of Medicine and Science , Los Angeles , CA , USA.
Hyman M Scottf Bridge HIV , San Francisco Department of Public Health , San Francisco , CA , USA.
Steven Shoptawg Department of Family Medicine , University of California Los Angeles , Los Angeles , CA , USA.
Carlos Del Rioh Department of Global Health , Emory University Rollins School of Public Health , Atlanta , GA , USA.
Manya Magnusi Department of Epidemiology and Biostatistics , The George Washington University , Washington , DC , USA.
Sharon Mannheimerj Department of Medicine, Harlem Hospital , Columbia University Mailman School of Public Health , New York , NY , USA.
Hong-Van Tieuk Laboratory of Infectious Disease Prevention , Lindsley F. Kimball Research Institute, New York Blood Center , New York , NY , USA.
Darrell P Wheelerl School of Social Welfare , University at Albany, State University of New York , Albany , NY , USA.
Kenneth H Mayerm The Fenway Institute , Fenway Health , Boston , MA , USA.
Beryl A Koblink Laboratory of Infectious Disease Prevention , Lindsley F. Kimball Research Institute, New York Blood Center , New York , NY , USA.
Susan H Eshlemana Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Fred Hutch Cancer Center · USJohns Hopkins University · USNew York Blood Center · USCharles R. Drew University of Medicine and Science · USColumbia University · USEmory University · USFamily Health International 360 · USGeorge Washington University · USHarvard University · USJohns Hopkins Medicine · USSan Francisco Department of Public Health · USUniversity at Albany, State University of New York · USUniversity of California, Los Angeles · US

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
UCLA AIDS Prevention and Treatment Clinical Trials UnitUM1AI069424 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith S. Currier, RAPHAEL J LANDOVITZ · 2012 to 2026
$51.8M
Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials UnitUM1AI069470 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK · 2012 to 2026
$44.8M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Minority Populations Prevention Researcher TrainingR25HD045810 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEILANDS, TORSTEN BRIAN · 2003 to 2018
$4.3M
Sexual Networks, Drugs, and HIV Risk among Men Who Have Sex With MenK01DA031035 · NIDA · NEW YORK BLOOD CENTER · PI TIEU, HONG VAN NHU · 2011 to 2015
$862k
PHASTT: A mobile Personalized HIV and STI Testing Tool for young Black menK23MH104116 · NIMH · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI SCOTT, HYMAN · 2015 to 2018
$762k
NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI069424NIAID NIH HHS UM1 AI069470NICHD NIH HHS R25 HD045810NIDA NIH HHS K01 DA031035NIGMS NIH HHS T32 GM008752NIMH NIH HHS K23 MH104116
6 · The paper itself

Abstract

objectiveTo evaluate factors associated with HIV tropism among Black men who have sex with men (MSM) in the United States enrolled in a clinical study (HIV Prevention Trials Network 061).

methodsHIV tropism was analyzed using a phenotypic assay (Trofile assay, Monogram Biosciences). Samples were analyzed from 43 men who were HIV infected at enrollment and reported either exclusive insertive intercourse or exclusive receptive intercourse; samples were also analyzed from 20 men who were HIV uninfected at enrollment and seroconverted during the study. Clonal analysis of individual viral variants was performed for seroconverters who had dual/mixed (DM) viruses.

resultsDM viruses were detected in samples from 11 (26%) of the 43 HIV-infected men analyzed at the enrollment visit; HIV tropism did not differ between those reporting exclusive insertive vs receptive intercourse. DM viruses were also detected in five (25%) of the 20 seroconverters. DM viruses were associated with lower CD4 cell counts. Seroconverters with DM viruses had dual-tropic viruses only or mixed populations of CCR5- and dual-tropic viruses.

conclusionsDM viruses were frequently detected among Black MSM in this study, including seroconverters. Further studies are needed to understand factors driving transmission and selection of CXCR4- and dual-tropic viruses among Black MSM.

Indexed as

Black or African AmericanHomosexuality, MaleAdolescentAdultAmino Acid SequenceCD4 Lymphocyte CountHIV-1HIV Envelope Protein gp120HIV InfectionsHumansMaleMiddle AgedPeptide FragmentsReceptors, CXCR4Receptors, HIVRisk FactorsHIV Envelope Protein gp120HIV envelope protein gp120 (305-321)Peptide FragmentsReceptors, CXCR4Receptors, HIVBlackCXCR4Dual/mixedDual-tropicHIVMen who have sex with menTropism

Identifiers

PMID27300696
PMCPMC5003405
OpenAlexW2425031436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.